EDITORIAL FEATURE:
Keys to Independence in the U.K. and Ireland

Anne Forde and Elisabeth Pain
Science 15 April 2005: 427-428.
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EDITORIAL FEATURE:
Views From the Trenches

Anne Forde and Elisabeth Pain
Science 15 April 2005: 428-430.
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This Week in Science

Editor summaries of this week's papers.
Science 15 April 2005: 321.
|Full Text »

Editorial:
In Search of a Lifeline

Mark Schaefer
Science 15 April 2005: 325.
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Editors' Choice

Highlights of the recent literature.
Science 15 April 2005: 326.
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NetWatch

Best of the Web in science.
Science 15 April 2005: 331.
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 New Products

Science 15 April 2005: 425.
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News of the Week

STEM CELLS:
Restiveness Grows at NIH Over Bush Research Restrictions

Constance Holden
Science 15 April 2005: 334-335.
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AIDS RESEARCH:
IOM Panel Clears HIV Prevention Study

Jennifer Couzin
Science 15 April 2005: 334.
Summary »|   Full Text »|   PDF »|  

NUCLEAR WASTE:
Academy Gets the Word Out After Tussle With Agency

Eli Kintisch
Science 15 April 2005: 335.
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GEOCHEMISTRY:
Gasping for Air in Permian Hard Times

Richard A. Kerr
Science 15 April 2005: 337.
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EUROPEAN SCIENCE:
A Second Entry in the Mars Sweepstakes

Mason Inman
Science 15 April 2005: 338-339.
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JAPAN:
Space Vision Backs Peer-Reviewed Science

Dennis Normile
Science 15 April 2005: 338.
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PARTICLE PHYSICS:
Magnetic Scope Angles for Axions

Charles Seife
Science 15 April 2005: 339.
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POPULATION GENETICS:
Private Partnership to Trace Human History

Elizabeth Pennisi
Science 15 April 2005: 340.
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TOXICOLOGY:
EPA Kills Florida Pesticide Study

Jocelyn Kaiser
Science 15 April 2005: 340.
Summary »|   Full Text »|   PDF »|  

ASIAN TSUNAMIS:
Model Shows Islands Muted Tsunami After Latest Indonesian Quake

Richard A. Kerr
Science 15 April 2005: 341.
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INFECTIOUS DISEASES:
Veterinary Scientists Shore Up Defenses Against Bird Flu

Martin Enserink
Science 15 April 2005: 341.
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ScienceScope

Science 15 April 2005: 337.
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Random Samples

Science 15 April 2005: 350.
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News Focus

EUROPEAN RESEARCH:
A Framework for Change?

Gretchen Vogel
Science 15 April 2005: 342-344.
Summary »|   Full Text »|   PDF »|  

EUROPEAN RESEARCH:
E.U. Wins Over Researchers With a Ticket to Ride

Eliot Marshall
Science 15 April 2005: 343.
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EUROPEAN RESEARCH:
The Dos and Don'ts of Getting an E.U. Grant

Martin Enserink
Science 15 April 2005: 344.
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ADDICTION RESEARCH:
Ibogaine Therapy: A 'Vast, Uncontrolled Experiment'

Brian Vastag
Science 15 April 2005: 345-346.
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ECOLOGY:
Experimental Drought Predicts Grim Future for Rainforest

Erik Stokstad
Science 15 April 2005: 346-347.
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SUPERCONDUCTIVITY:
New Wave of Electrical Wires Inches Closer to Market

Robert F. Service
Science 15 April 2005: 348-349.
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Letters

This Week's Letters

Science 15 April 2005: 353.
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 The Problem with Patents

Malcolm Cronlund
Science 15 April 2005: 353.
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 Defining the Concept of Public Information

Sasha R. X. Dall;, Arnon Lotem, David W. Winkler;, Peter A. Bednekoff;, Kevin N. Laland, Isabelle Coolen, Rachel Kendal;, Étienne Danchin, Luc-Alain Giraldeau, Thomas J. Valone, and Richard H. Wagner
Science 15 April 2005: 353-356.
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 PLOS Position on NIH Public Access Policy

Andy Gass and Helen Doyle
Science 15 April 2005: 356.
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 Corrections and Clarifications

Science 15 April 2005: 356.
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Books et al.

NEUROSCIENCE:
Treasures from a Golden Age

Robert Wurtz
Science 15 April 2005: 357-358.
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MARINE ECOLOGY:
Toward Ecosystems Oceanography

Philippe Cury
Science 15 April 2005: 358.
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 Books Received

Science 15 April 2005: 358.

Policy Forum

ECOLOGY:
Enhanced: Importing Timber, Exporting Ecological Impact

Audrey L. Mayer, Pekka E. Kauppi, Per K. Angelstam, Yu Zhang, and Päivi M. Tikka
Science 15 April 2005: 359-360.
Summary »|   Full Text »|   PDF »|  

Perspectives

OCEAN SCIENCE:
Coral Clues to Rapid Sea-Level Change

Gideon M. Henderson
Science 15 April 2005: 361-362.
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GENETICS:
Was the Human Genome Project Worth the Effort?

Stephen P. Daiger
Science 15 April 2005: 362-364.
Published online 15 March 2005 [DOI: 10.1126/science.1111655] (in Science Express Perspectives)
Summary »|   Full Text »|   PDF »|  

CELL BIOLOGY:
Of Grainy Heads and Broken Skins

Nicholas Harden
Science 15 April 2005: 364-365.
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EVOLUTION:
Life on the Early Earth: A Sedimentary View

Frances Westall
Science 15 April 2005: 366-367.
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CHEMISTRY:
A New Route to Designer Antibiotics

Chaitan Khosla and Yi Tang
Science 15 April 2005: 367-368.
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Review

Unveiling the Mechanisms of Cell-Cell Fusion

Elizabeth H. Chen and Eric N. Olson
Science 15 April 2005: 369-373.
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Brevia

A Pair of Shelled Eggs Inside A Female Dinosaur

Tamaki Sato, Yen-nien Cheng, Xiao-chun Wu, Darla K. Zelenitsky, and Yu-fu Hsiao
Science 15 April 2005: 375.
A new dinosaur fossil contains two eggs in the abdominal cavity, suggesting that these animals had two oviducts, like crocodiles, but ovulated only one egg in each, like birds. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Research Articles

Impact of Humans on the Flux of Terrestrial Sediment to the Global Coastal Ocean

James P. M. Syvitski, Charles J. Vörösmarty, Albert J. Kettner, and Pamela Green
Science 15 April 2005: 376-380.
Although human activities have increased erosion globally, dams have now decreased the quantity of sediment delivered to the oceans compared to pre-agricultural times. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

An Epidermal Barrier Wound Repair Pathway in Drosophila Is Mediated by grainy head

Kimberly A. Mace, Joseph C. Pearson, and William McGinnis
Science 15 April 2005: 381-385.
Insects and mammals seem to use the same hormonal response pathway to repair a wound in the surface layers of their skin. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Complement Factor H Polymorphism in Age-Related Macular Degeneration

Robert J. Klein, Caroline Zeiss, Emily Y. Chew, Jen-Yue Tsai, Richard S. Sackler, Chad Haynes, Alice K. Henning, John Paul SanGiovanni, Shrikant M. Mane, Susan T. Mayne, Michael B. Bracken, Frederick L. Ferris, Jurg Ott, Colin Barnstable, and Josephine Hoh
Science 15 April 2005: 385-389.
Published online 10 March 2005 [DOI: 10.1126/science.1109557] (in Science Express Research Articles)
People with a common variant of a gene that modulates inflammation have a greater risk of developing macular degeneration, the leading cause of blindness in the elderly. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Reports

Quantum Phase Transition of a Magnet in a Spin Bath

H. M. Rønnow, R. Parthasarathy, J. Jensen, G. Aeppli, T. F. Rosenbaum, and D. F. McMorrow
Science 15 April 2005: 389-392.
A magnet tuned to a quantum critical point exhibits coupling of electronic and nuclear spins, possibly helping to explain the behavior of quantum information processing schemes. Abstract »|   Full Text »|   PDF »|  

Atomic-Scale Visualization of Inertial Dynamics

A. M. Lindenberg, J. Larsson, K. Sokolowski-Tinten, K. J. Gaffney, C. Blome, O. Synnergren, J. Sheppard, C. Caleman, A. G. MacPhee, D. Weinstein, D. P. Lowney, T. K. Allison, T. Matthews, R. W. Falcone, A. L. Cavalieri, D. M. Fritz, S. H. Lee, P. H. Bucksbaum, D. A. Reis, J. Rudati, P. H. Fuoss, C. C. Kao, D. P. Siddons, R. Pahl, J. Als-Nielsen, S. Duesterer, R. Ischebeck, H. Schlarb, H. Schulte-Schrepping, Th. Tschentscher, J. Schneider, D. von der Linde, O. Hignette, F. Sette, H. N. Chapman, R. W. Lee, T. N. Hansen, S. Techert, J. S. Wark, M. Bergh, G. Huldt, D. van der Spoel, N. Timneanu, J. Hajdu, R. A. Akre, E. Bong, P. Krejcik, J. Arthur, S. Brennan, K. Luening, and J. B. Hastings
Science 15 April 2005: 392-395.
Atomic imaging using fast x-ray pulses shows that if you melt a solid rapidly it becomes like a liquid with the atoms moving randomly in their original crystalline positions. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

A Convergent Enantioselective Route to Structurally Diverse 6-Deoxytetracycline Antibiotics

Mark G. Charest, Christian D. Lerner, Jason D. Brubaker, Dionicio R. Siegel, and Andrew G. Myers
Science 15 April 2005: 395-398.
Artificial tetracycline is formed by joining two independently synthesized halves of the molecule, enabling easy chemical modification to combat the development of antibiotic resistance. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Hypoxia, Global Warming, and Terrestrial Late Permian Extinctions

Raymond B. Huey and Peter D. Ward
Science 15 April 2005: 398-401.
A drop in atmospheric oxygen to below-present levels and pronounced warming may have led to the catastrophic end-Permian extinctions. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Open-System Coral Ages Reveal Persistent Suborbital Sea-Level Cycles

William G. Thompson and Steven L. Goldstein
Science 15 April 2005: 401-404.
Coral dating that corrects for exchange of uranium decay products with sea water reveals that sea level varied repeatedly by up to 30 meters during recent glaciations. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Fragmentation and Flow Regulation of the World's Large River Systems

Christer Nilsson, Catherine A. Reidy, Mats Dynesius, and Carmen Revenga
Science 15 April 2005: 405-408.
Flow in more than half of the world's large river systems, including eight located in the most diverse habitats, is affected by dams. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Crystal Structure of the Malaria Vaccine Candidate Apical Membrane Antigen 1

Juan Carlos Pizarro, Brigitte Vulliez-Le Normand, Marie-Laure Chesne-Seck, Christine R. Collins, Chrislaine Withers-Martinez, Fiona Hackett, Michael J. Blackman, Bart W. Faber, Edmond J. Remarque, Clemens H. M. Kocken, Alan W. Thomas, and Graham A. Bentley
Science 15 April 2005: 408-411.
Published online 24 February 2005 [DOI: 10.1126/science.1107449] (in Science Express Reports)
The structure of a membrane protein from the malaria parasite reveals that one domain is critical for helping the parasite invade host cells, potentially facilitating vaccine and drug design. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

A Homolog of Drosophila grainy head Is Essential for Epidermal Integrity in Mice

Stephen B. Ting, Jacinta Caddy, Nikki Hislop, Tomasz Wilanowski, Alana Auden, Lin-lin Zhao, Sarah Ellis, Pritinder Kaur, Yoshikazu Uchida, Walter M. Holleran, Peter M. Elias, John M. Cunningham, and Stephen M. Jane
Science 15 April 2005: 411-413.
Insects and mammals seem to use the same hormonal response pathway to repair a wound in the surface layers of their skin. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Reconstitution of Circadian Oscillation of Cyanobacterial KaiC Phosphorylation in Vitro

Masato Nakajima, Keiko Imai, Hiroshi Ito, Taeko Nishiwaki, Yoriko Murayama, Hideo Iwasaki, Tokitaka Oyama, and Takao Kondo
Science 15 April 2005: 414-415.
The biological clock for the daily rhythm of cyanobacteria can be reconstituted in vitro by three proteins plus ATP, which interact to sustain oscillations. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Representation of Visual Gravitational Motion in the Human Vestibular Cortex

Iole Indovina, Vincenzo Maffei, Gianfranco Bosco, Myrka Zago, Emiliano Macaluso, and Francesco Lacquaniti
Science 15 April 2005: 416-419.
To estimate the time to collision of a falling object, the visual system depends on a computation of the acceleration due to gravity provided by the vestibular system. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Complement Factor H Variant Increases the Risk of Age-Related Macular Degeneration

Jonathan L. Haines, Michael A. Hauser, Silke Schmidt, William K. Scott, Lana M. Olson, Paul Gallins, Kylee L. Spencer, Shu Ying Kwan, Maher Noureddine, John R. Gilbert, Nathalie Schnetz-Boutaud, Anita Agarwal, Eric A. Postel, and Margaret A. Pericak-Vance
Science 15 April 2005: 419-421.
Published online 10 March 2005 [DOI: 10.1126/science.1110359] (in Science Express Reports)
People with a common variant of a gene that modulates inflammation have a greater risk of developing macular degeneration, the leading cause of blindness in the elderly. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Complement Factor H Polymorphism and Age-Related Macular Degeneration

Albert O. Edwards, Robert Ritter, III, Kenneth J. Abel, Alisa Manning, Carolien Panhuysen, and Lindsay A. Farrer
Science 15 April 2005: 421-424.
Published online 10 March 2005 [DOI: 10.1126/science.1110189] (in Science Express Reports)
People with a common variant of a gene that modulates inflammation have a greater risk of developing macular degeneration, the leading cause of blindness in the elderly. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Technical Comments

 Comment on "Grain Boundary-Mediated Plasticity in Nanocrystalline Nickel"

Mingwei Chen and Xiaoqin Yan
Science 15 April 2005: 356.
Full Text »|   PDF »|   Supporting Online Material »|  

 Response to Comment on "Grain Boundary-Mediated Plasticity in Nanocrystalline Nickel"

Zhiwei Shan, E. A. Stach, J. M. K. Wiezorek, J. A. Knapp, D. M. Follstaedt, and S. X. Mao
Science 15 April 2005: 356.
Full Text »|   PDF »|   Supporting Online Material »|