This Week in Science

Editor summaries of this week's papers.
Science 17 September 2004: 1673.
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Editorial:
Talking with North Korea

Norman P. Neureiter
Science 17 September 2004: 1677.
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Editors' Choice

Highlights of the recent literature.
Science 17 September 2004: 1679.
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NetWatch

Best of the Web in science.
Science 17 September 2004: 1687.
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 New Products

Science 17 September 2004: 1791.
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News of the Week

MANAGING SCIENCE:
House Votes to Kill Grants, Limit Travel to Meetings

Jocelyn Kaiser
Science 17 September 2004: 1688.
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SPACE PROGRAM:
Aiming for the Sun, Crashing to Earth

Richard A. Kerr
Science 17 September 2004: 1689.
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SCIENCE POLICY:
The Candidates Speak on Science

Science 17 September 2004: 1689.
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MEDICINE:
Possible New Role for BRCA2

Jean Marx
Science 17 September 2004: 1691.
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DATA SECURITY:
Report Upholds Public Access to Genetic Codes

David Malakoff
Science 17 September 2004: 1692.
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WOMEN IN SCIENCE:
Harvard Faculty Decry Widening Gender Gap

Yudhijit Bhattacharjee
Science 17 September 2004: 1692.
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PALEOCEANOGRAPHY:
Signs of a Warm, Ice-Free Arctic

Richard A. Kerr
Science 17 September 2004: 1693.
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DRUG RESEARCH:
Legislators Propose a Registry to Track Clinical Trials From Start to Finish

Jennifer Couzin
Science 17 September 2004: 1695.
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ScienceScope

Science 17 September 2004: 1691.
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Random Samples

Science 17 September 2004: 1709.
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News Focus

NORTH KOREA:
Visiting the Hermit Kingdom

Richard Stone
Science 17 September 2004: 1696.
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SCIENTIFIC EXCHANGES:
A Wary Pas de Deux

Richard Stone
Science 17 September 2004: 1696-1703.
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SCIENTIFIC EXCHANGES:
Nukes for Windmills: Quixotic or Serious Proposition?

Richard Stone
Science 17 September 2004: 1698-1699.
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SCIENTIFIC EXCHANGES:
The Ultimate, Exclusive LAN

Richard Stone
Science 17 September 2004: 1701.
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GEOCHEMISTRY:
In Mass Extinction, Timing Is All

Richard A. Kerr
Science 17 September 2004: 1705.
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BIOTERRORISM:
Biosecurity Goes Global

David Malakoff
Science 17 September 2004: 1706-1707.
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Letters

This Week's Letters

Science 17 September 2004: 1713.
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 Hollywood, Climate Change, and the Public

Andrew Balmford, Andrea Manica, Lesley Airey, Linda Birkin, Amy Oliver, and Judith Schleicher
Science 17 September 2004: 1713.
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 Evidence for Taming of Cats

Tom Rothwell;, J.-D. Vigne, and J. Guilaine
Science 17 September 2004: 1714.
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 Figuring Out What Works in Education

Arlene Fink
Science 17 September 2004: 1715.
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 CORRECTIONS AND CLARIFICATIONS

Science 17 September 2004: 1715.
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Books et al.

ENVIRONMENT:
How Best to Face the Coming Storm

Partha Dasgupta
Science 17 September 2004: 1716.
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ANTHROPOLOGY:
Culture and Commerce in a Seafood Bazaar

Stephen Gudeman
Science 17 September 2004: 1716-1717.
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 Browsings

Science 17 September 2004: 1717.
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 Books Received

Science 17 September 2004: 1717.

Policy Forum

GENETICS:
Ethical Aspects of ES Cell-Derived Gametes

Giuseppe Testa* and John Harris
Science 17 September 2004: 1719.
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Perspectives

NEUROSCIENCE:
Signposts to the Essence of Language

Michael Siegal
Science 17 September 2004: 1720-1721.
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CELL BIOLOGY:
Double Membrane Fusion

Nikolaus Pfanner, Nils Wiedemann, and Chris Meisinger
Science 17 September 2004: 1723-1724.
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CHEMISTRY:
Japan Bats a Triple

Robert West
Science 17 September 2004: 1724-1725.
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CHEMISTRY:
Enhanced: A Dash of Proline Makes Things Sweet

Erik J. Sorensen and Glenn M. Sammis
Science 17 September 2004: 1725-1726.
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BIOMEDICINE:
Eosinophils in Asthma: Remodeling a Tangled Tale

Marsha Wills-Karp and Christopher L. Karp
Science 17 September 2004: 1726-1729.
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PLANETARY SCIENCE:
Predicting the Sun's Oxygen Isotope Composition

Qing-zhu Yin
Science 17 September 2004: 1729-1730.
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Reviews

Living with the Past: Evolution, Development, and Patterns of Disease

Peter D. Gluckman and Mark A. Hanson
Science 17 September 2004: 1733-1736.
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Inflammatory Exposure and Historical Changes in Human Life-Spans

Caleb E. Finch and Eileen M. Crimmins
Science 17 September 2004: 1736-1739.
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Brevia

Direct Sub-Angstrom Imaging of a Crystal Lattice

P. D. Nellist, M. F. Chisholm, N. Dellby, O. L. Krivanek, M. F. Murfitt, Z. S. Szilagyi, A. R. Lupini, A. Borisevich, W. H. Sides, Jr., and S. J. Pennycook
Science 17 September 2004: 1741.
Correcting for spherical aberrations in its imaging lens improves the resolution of a transmission electron microscope to less than one angstrom. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Research Articles

Environmentally Induced Foregut Remodeling by PHA-4/FoxA and DAF-12/NHR

Wanyuan Ao, Jeb Gaudet, W. James Kent, Srikanth Muttumu, and Susan E. Mango
Science 17 September 2004: 1743-1746.
Clusters of genes activated in different cell types of the developing worm form a regulatory network that directs foregut development in response to external stimuli. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Mitochondrial Fusion Intermediates Revealed in Vitro

Shelly Meeusen, J. Michael McCaffery, and Jodi Nunnari
Science 17 September 2004: 1747-1752.
Published online 5 August 2004 [DOI: 10.1126/science.1100612] (in Science Express Research Articles)
Mitochondria, the double membrane-bound organelles that generate energy for the cell, fuse with one another using quite different mechanisms for joining the inner and outer membranes. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Reports

Two-Step Synthesis of Carbohydrates by Selective Aldol Reactions

Alan B. Northrup and David W. C. MacMillan
Science 17 September 2004: 1752-1755.
Published online 12 August 2004 [DOI: 10.1126/science.1101710] (in Science Express Reports)
A two-step sequence using proline as a catalyst greatly simplifies the synthesis of chirally pure hexose sugars from three achiral aldehyde precursors. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

A Stable Compound Containing a Silicon-Silicon Triple Bond

Akira Sekiguchi, Rei Kinjo, and Masaaki Ichinohe
Science 17 September 2004: 1755-1757.
A compound containing a silicon-silicon triple bond, the silicon analog of an alkyne, is synthesized and shown to form stable green crystals. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

A Linear, O-Coordinated ¹-CO₂ Bound to Uranium

Ingrid Castro-Rodriguez, Hidetaka Nakai, Lev N. Zakharov, Arnold L. Rheingold, and Karsten Meyer
Science 17 September 2004: 1757-1759.
In a new coordination mode, carbon dioxide can bond to a uranium complex end-on, through its oxygen atom. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Age and Timing of the Permian Mass Extinctions: U/Pb Dating of Closed-System Zircons

Roland Mundil, Kenneth R. Ludwig, Ian Metcalfe, and Paul R. Renne
Science 17 September 2004: 1760-1763.
Zircons from ash beds, annealed and treated with HF acid, yield accurate and consistent dates for the Permian Triassic extinction of 252.6 million years ago and confirm that it occurred within 300,000 years. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Molecular Cloud Origin for the Oxygen Isotope Heterogeneity in the Solar System

Hisayoshi Yurimoto and Kiyoshi Kuramoto
Science 17 September 2004: 1763-1766.
A model suggests that the characteristic oxygen isotopes of early meteorites are a result of ultraviolet radiation of carbon monoxide, which was then transported on dust to inner parts of the solar system. Abstract »|   Full Text »|   PDF »|  

Middle Miocene Southern Ocean Cooling and Antarctic Cryosphere Expansion

Amelia E. Shevenell, James P. Kennett, and David W. Lea
Science 17 September 2004: 1766-1770.
Changes in ocean circulation affected by Earth's orbit, not low atmospheric CO₂ levels, may have initiated the expansion of Antarctic ice sheets 14 million years ago. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Crystal Structure of a Shark Single-Domain Antibody V Region in Complex with Lysozyme

Robyn L. Stanfield, Helen Dooley, Martin F. Flajnik, and Ian A. Wilson
Science 17 September 2004: 1770-1773.
Published online 19 August 2004 [DOI: 10.1126/science.1101148] (in Science Express Reports)
Single-chain antibodies from the nurse shark contain two antigen-recognizing regions, whereas mammals have three, yet the shark antibodies bind just as tightly. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Defining a Link with Asthma in Mice Congenitally Deficient in Eosinophils

James J. Lee, Dawn Dimina, MiMi P. Macias, Sergei I. Ochkur, Michael P. McGarry, Katie R. O'Neill, Cheryl Protheroe, Ralph Pero, Thanh Nguyen, Stephania A. Cormier, Elizabeth Lenkiewicz, Dana Colbert, Lisa Rinaldi, Steven J. Ackerman, Charles G. Irvin, and Nancy A. Lee
Science 17 September 2004: 1773-1776.
An immune cell that appears in the mouse lung during asthma-like attacks seems to cause rapid lung dysfunction and later to produce changes in lung structure. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

A Critical Role for Eosinophils in Allergic Airways Remodeling

Alison A. Humbles, Clare M. Lloyd, Sarah J. McMillan, Daniel S. Friend, Georgina Xanthou, Erin. E. McKenna, Sorina Ghiran, Norma P. Gerard, Channing Yu, Stuart H. Orkin, and Craig Gerard
Science 17 September 2004: 1776-1779.
An immune cell that appears in the mouse lung during asthma-like attacks seems to cause rapid lung dysfunction and later to produce changes in lung structure. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Children Creating Core Properties of Language: Evidence from an Emerging Sign Language in Nicaragua

Ann Senghas, Sotaro Kita, and Asli Özyürek
Science 17 September 2004: 1779-1782.
A sign language developed by deaf children consists of discrete units similar to those of spoken language, perhaps reflecting the fundamental organization of the brain's language centers. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Two Distinct Actin Networks Drive the Protrusion of Migrating Cells

A. Ponti, M. Machacek, S. L. Gupton, C. M. Waterman-Storer, and G. Danuser
Science 17 September 2004: 1782-1786.
The leading edge of moving cells contains a population of actin molecules involved with membrane protrusion and retraction and another that powers the cell's movement. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Zooming In on a Quantitative Trait for Tomato Yield Using Interspecific Introgressions

Eyal Fridman, Fernando Carrari, Yong-Sheng Liu, Alisdair R. Fernie, and Dani Zamir
Science 17 September 2004: 1786-1789.
The sweetness of ketchup tomatoes is partly determined by a single point mutation in the enzyme that generates glucose and fructose. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Technical Comments

 Comment on "The Early Evolution of the Tetrapod Humerus"

P. E. Ahlberg
Science 17 September 2004: 1715.
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 Response to Comment on "The Early Evolution of the Tetrapod Humerus"

Michael I. Coates, Neil H. Shubin, and Edward B. Daeschler
Science 17 September 2004: 1715.
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