Piecing Together Human Aging

Deconstructing Aging

Lisa Chong, Heather McDonald, and and Evelyn Strauss
Science 3 September 2004: 1419.
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News

Coming to Grips With Bone Loss

Jean Marx
Science 3 September 2004: 1420-1422.
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Viewpoint

Aging in Rhesus Monkeys: Relevance to Human Health Interventions

George S. Roth, Julie A. Mattison, Mary Ann Ottinger, Mark E. Chachich, Mark A. Lane, and Donald K. Ingram
Science 3 September 2004: 1423-1426.
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Review

What Can Progeroid Syndromes Tell Us About Human Aging?

David Kipling, Terence Davis, Elizabeth L. Ostler, and Richard G. A. Faragher
Science 3 September 2004: 1426-1431.
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This Week in Science

Editor summaries of this week's papers.
Science 3 September 2004: 1365.
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Editorial:
Longevity, Quality, and the One-Hoss Shay

Donald Kennedy
Science 3 September 2004: 1369.
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Editors' Choice

Highlights of the recent literature.
Science 3 September 2004: 1371.
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NetWatch

Best of the Web in science.
Science 3 September 2004: 1381.
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 New Products

Science 3 September 2004: 1477.
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News of the Week

EXTRASOLAR PLANETS:
Planet Hunting Gets Rocky As Teams Clash Over Small Worlds

Robert Irion
Science 3 September 2004: 1382.
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DEVELOPMENTAL BIOLOGY:
Bonemaking Protein Shapes Beaks of Darwin's Finches

Elizabeth Pennisi
Science 3 September 2004: 1383.
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VIROLOGY:
Avian Flu Finds New Mammal Hosts

Martin Enserink and Jocelyn Kaiser
Science 3 September 2004: 1385.
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PALEONTOLOGY:
400-Million-Year-Old Wounds Reveal a Time When Predators Romped

Erik Stokstad
Science 3 September 2004: 1386.
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SCIENTIFIC PUBLISHING:
Zerhouni Plans a Nudge Toward Open Access

Jocelyn Kaiser
Science 3 September 2004: 1386.
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MEETINGS:
Europe Clones U.S. Science Festival

Martin Enserink
Science 3 September 2004: 1387.
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PRESIDENTIAL APPOINTMENTS:
NSF's Acting Chief Facing Legal Limit on Tenure

Jeffrey Mervis
Science 3 September 2004: 1389.
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ACADEMIC LEADERS:
Neuroscientist Named MIT President

Andrew Lawler
Science 3 September 2004: 1389.
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ScienceScope

Science 3 September 2004: 1385.
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Random Samples

Science 3 September 2004: 1398.
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News Focus

NEUROBIOLOGY:
Making Sense of Tourette's

Steve Olson
Science 3 September 2004: 1390-1392.
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HIGH-ENERGY ASTROPHYSICS:
Telescopes Break New Ground in Quest for Cosmic Rays

Daniel Clery
Science 3 September 2004: 1393-1395.
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7TH INTERNATIONAL CONGRESS ON VERTEBRATE MORPHOLOGY MEETING:
Newly Hatched Dinosaur Babies Hit the Ground Running

Elizabeth Pennisi
Science 3 September 2004: 1396.
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7TH INTERNATIONAL CONGRESS ON VERTEBRATE MORPHOLOGY MEETING:
Tiny Salamanders Show Their Teeth

Elizabeth Pennisi
Science 3 September 2004: 1396-1397.
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7TH INTERNATIONAL CONGRESS ON VERTEBRATE MORPHOLOGY MEETING:
Snake Tartare--Quite a Bodyful

Elizabeth Pennisi
Science 3 September 2004: 1397.
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Letters

This Week's Letters

Science 3 September 2004: 1401.
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 Disclosure of Clinical Trials in Children

Maurizio Bonati, Chiara Pandolfini, and Antonio Clavenna
Science 3 September 2004: 1401.
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 Antidepressants' Use in Anorexic Girls

Per Södersten and Cecilia Bergh
Science 3 September 2004: 1401.
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 SSRIs in Children and Suicide

Donald F. Klein
Science 3 September 2004: 1401.
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 Disparities in Cancer Funding

Phillip A. Dennis
Science 3 September 2004: 1401-1402.
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 The Case Against Stem Cell Research

John T. Durkin
Science 3 September 2004: 1402.
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 Problems in FBI mtDNA Database

Hans-Jürgen Bandelt, Antonio Salas, and Claudio Bravi
Science 3 September 2004: 1402-1404.
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 CORRECTIONS AND CLARIFICATIONS

Science 3 September 2004: 1404.
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Books et al.

PHILOSOPHY OF SCIENCE:
The Embryo of a Dialogue

Günter P. Wagner
Science 3 September 2004: 1405-1406.
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HISTORY OF SCIENCE:
The First Lord from Science

John S. Rigden
Science 3 September 2004: 1406.
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 Books Received

Science 3 September 2004: 1406.

Essays on Science and Society

BEYOND THE IVORY TOWER:
A World of Glass

Alan Macfarlane and Gerry Martin
Science 3 September 2004: 1407-1408.
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Perspectives

MOLECULAR BIOLOGY:
Argonaute Journeys into the Heart of RISC

Erik J. Sontheimer and Richard W. Carthew
Science 3 September 2004: 1409-1410.
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PHYSICS:
Crystalline Electron Pairs

Marcel Franz
Science 3 September 2004: 1410-1411.
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MEDICINE:
Targeting Apoptotic Pathways in Cancer Cells

Catherine Denicourt and Steven F. Dowdy
Science 3 September 2004: 1411-1413.
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ECOLOGY:
Spite Among Siblings

Andy Gardner and Stuart A. West
Science 3 September 2004: 1413-1414.
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PLANETARY SCIENCE:
Enhanced: Looking into the Giant Planets

Jonathan J. Fortney
Science 3 September 2004: 1414-1415.
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Brevia

Evolution of Coral Pigments Recreated

Juan A. Ugalde, Belinda S. W. Chang, and Mikhail V. Matz
Science 3 September 2004: 1433.
In the great star coral, the green fluorescent protein appeared early in evolution, and more complex red versions arose independently later. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Research Articles

Crystal Structure of Argonaute and Its Implications for RISC Slicer Activity

Ji-Joon Song, Stephanie K. Smith, Gregory J. Hannon, and Leemor Joshua-Tor
Science 3 September 2004: 1434-1437.
Published online 29 July 2004 [DOI: 10.1126/science.1102514] (in Science Express Research Articles)
The protein responsible for targeting and destroying RNA in RNAi has been identified, and its structure determined. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Argonaute2 Is the Catalytic Engine of Mammalian RNAi

Jidong Liu, Michelle A. Carmell, Fabiola V. Rivas, Carolyn G. Marsden, J. Michael Thomson, Ji-Joon Song, Scott M. Hammond, Leemor Joshua-Tor, and Gregory J. Hannon
Science 3 September 2004: 1437-1441.
Published online 29 July 2004 [DOI: 10.1126/science.1102513] (in Science Express Research Articles)
The protein responsible for targeting and destroying RNA in RNAi has been identified, and its structure determined. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Reports

Substructure in the Circumstellar Disk Around the Young Star AU Microscopii

Michael C. Liu
Science 3 September 2004: 1442-1444.
Published online 12 August 2004 [DOI: 10.1126/science.1102929] (in Science Express Reports)
Variation in the thickness and brightness of the dusty disk around a nearby star, as seen with the Keck telescope, may indicate the presence of extrasolar planets. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Electrically Driven Single-Cell Photonic Crystal Laser

Hong-Gyu Park, Se-Heon Kim, Soon-Hong Kwon, Young-Gu Ju, Jin-Kyu Yang, Jong-Hwa Baek, Sung-Bock Kim, and Yong-Hee Lee
Science 3 September 2004: 1444-1447.
An infrared laser, operating at room temperature, has been produced from a small photonic crystal that is pumped electrically, not optically, at a low threshold current. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Macroscopic, Neat, Single-Walled Carbon Nanotube Fibers

Lars M. Ericson, Hua Fan, Haiqing Peng, Virginia A. Davis, Wei Zhou, Joseph Sulpizio, Yuhuang Wang, Richard Booker, Juraj Vavro, Csaba Guthy, A. Nicholas G. Parra-Vasquez, Myung Jong Kim, Sivarajan Ramesh, Rajesh K. Saini, Carter Kittrell, Gerry Lavin, Howard Schmidt, W. Wade Adams, W. E. Billups, Matteo Pasquali, Wen-Fang Hwang, Robert H. Hauge, John E. Fischer, and Richard E. Smalley
Science 3 September 2004: 1447-1450.
Ropes, hundreds of nanometers in diameter, made of single-walled carbon nanotubes and containing smaller braided bundles, can be spun from a superacid solution containing dissolved carbon nanotubes. Abstract »|   Full Text »|   PDF »|  

External and Internal Morphology of the BAR 1002'00 Orrorin tugenensis Femur

K. Galik, B. Senut, M. Pickford, D. Gommery, J. Treil, A. J. Kuperavage, and R. B. Eckhardt
Science 3 September 2004: 1450-1453.
The detailed internal structure of a femur dating to 6 million years ago, imaged with computerized tomography, confirms that Orrorin tugenensis, was an early bipedal hominid. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Testing Predator-Driven Evolution with Paleozoic Crinoid Arm Regeneration

Tomasz K. Baumiller and Forest J. Gahn
Science 3 September 2004: 1453-1455.
The proportion of fossil crinoids that lost arms to predators increased about 400 million years ago, supporting the notion that predation helped drive rapid evolution then. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Polymorphism in Presolar Al₂O₃ Grains from Asymptotic Giant Branch Stars

Rhonda M. Stroud, Larry R. Nittler, and Conel M. O'D. Alexander
Science 3 September 2004: 1455-1457.
The isotopic composition and titanium content of crystalline and amorphous alumina grains from the Tieschitz meteorite indicate that these grains are derived from asymptotic giant branch stars. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Reverse Methanogenesis: Testing the Hypothesis with Environmental Genomics

Steven J. Hallam, Nik Putnam, Christina M. Preston, John C. Detter, Daniel Rokhsar, Paul M. Richardson, and Edward F. DeLong
Science 3 September 2004: 1457-1462.
Methane-producing bacteria in ocean sediments coexist with Archaea that can anaerobically oxidize methane by running the methane-generating reaction in reverse. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Bmp4 and Morphological Variation of Beaks in Darwin's Finches

Arhat Abzhanov, Meredith Protas, B. Rosemary Grant, Peter R. Grant, and Clifford J. Tabin
Science 3 September 2004: 1462-1465.
The distribution of a key growth factor very early in development shapes the duck's bill and the chicken's beak, as well as the more subtle structural differences among the beaks of Galapagos finches. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Molecular Shaping of the Beak

Ping Wu, Ting-Xin Jiang, Sanong Suksaweang, Randall Bruce Widelitz, and Cheng-Ming Chuong
Science 3 September 2004: 1465-1466.
The distribution of a key growth factor very early in development shapes the duck's bill and the chicken's beak, as well as the more subtle structural differences among the beaks of Galapagos finches. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix

Loren D. Walensky, Andrew L. Kung, Iris Escher, Thomas J. Malia, Scott Barbuto, Renee D. Wright, Gerhard Wagner, Gregory L. Verdine, and Stanley J. Korsmeyer
Science 3 September 2004: 1466-1470.
Two potential new drugs—one a chemically stabilized portion of a cellular protein and the other a small molecular substitute for a key protein-protein interaction—trigger cell death and may be useful in treating cancer. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

A Small Molecule Smac Mimic Potentiates TRAIL- and TNF-Mediated Cell Death

Lin Li, Ranny Mathew Thomas, Hidetaka Suzuki, Jef K. De Brabander, Xiaodong Wang, and Patrick G. Harran
Science 3 September 2004: 1471-1474.
Two potential new drugs—one a chemically stabilized portion of a cellular protein and the other a small molecular substitute for a key protein-protein interaction—trigger cell death and may be useful in treating cancer. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

The Emergence of Competition Between Model Protocells

Irene A. Chen, Richard W. Roberts, and Jack W. Szostak
Science 3 September 2004: 1474-1476.
RNA encapsulated within a membrane can drive the growth of its surrounding vesicle, suggesting how improved RNA replication might have been selected for in a prebiotic world. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Technical Comments

 Comment on "Inhibition of Hepatitis B Virus Replication by APOBEC3G"

Christine Rösler, Josef Köck, Michael H. Malim, Hubert E. Blum, and Fritz von Weizsäcker
Science 3 September 2004: 1403.
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 Response to Comment on "Inhibition of Hepatitis B Virus Replication by APOBEC3G"

Priscilla Turelli, Stéphanie Jost, Bastien Mangeat, and Didier Trono
Science 3 September 2004: 1403.
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