HIV/AIDS in Asia

A Time for Action

Colin Norman
Science 25 June 2004: 1931.
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News

Asia and Africa: On Different Trajectories?

Jon Cohen
Science 25 June 2004: 1932-1938.
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The Asian Epidemic Model's Provocative Curves

Jon Cohen
Science 25 June 2004: 1934.
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Monitoring Treatment: At What Cost?

Jon Cohen
Science 25 June 2004: 1936.
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TREAT Asia Spans the Continental Divide

Jon Cohen
Science 25 June 2004: 1938.
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This Week in Science

Editor summaries of this week's papers.
Science 25 June 2004: 1871.
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Editorial:
Access for All?

Joep M. A. Lange and Vallop Thaineua
Science 25 June 2004: 1875.
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Editors' Choice

Highlights of the recent literature.
Science 25 June 2004: 1877.
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NetWatch

Best of the Web in science.
Science 25 June 2004: 1883.
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 AAAS News & Notes

Science 25 June 2004: 1921-1925.

 New Products

Science 25 June 2004: 1993.
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News of the Week

NONPROLIFERATION:
Coalition Throws 11th-Hour Lifeline to Iraqi Weaponeers

Richard Stone
Science 25 June 2004: 1884.
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ITER:
Crunch Time, Again, on Fusion Project

Daniel Clery
Science 25 June 2004: 1885.
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EUROPEAN FUNDING:
E.U. Proposes Bigger Framework Plus a Bonus for Researchers

Gretchen Vogel
Science 25 June 2004: 1885-1887.
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OCEAN RESEARCH:
Tight NSF Budget Means Less Time at Sea for University Fleet

Jeffrey Mervis
Science 25 June 2004: 1887.
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NEUROSCIENCE:
The Mice That Don't Miss Mom: Love and the μ-Opioid Receptor

Mary Beckman
Science 25 June 2004: 1888-1889.
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2004 ELECTION:
Kerry Blasts Bush Over U.S. Science

Andrew Lawler
Science 25 June 2004: 1888.
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ARCHAEOLOGY:
Putting the Stone in Stonehenge

Richard Stone
Science 25 June 2004: 1889-1891.
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NATIONAL INSTITUTES OF HEALTH:
Panel Weighs Starter R01 Grants

Jocelyn Kaiser
Science 25 June 2004: 1891.
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OCCUPATIONAL HEALTH:
Authors Turn Up Heat Over Disputed Paper

Dan Ferber
Science 25 June 2004: 1891.
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ScienceScope

Science 25 June 2004: 1887.
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Random Samples

Science 25 June 2004: 1900.
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News Focus

BIOMONITORING:
Pollution Gets Personal

Erik Stokstad
Science 25 June 2004: 1892-1894.
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BIOMONITORING:
A Snapshot of the U.S. Chemical Burden

Erik Stokstad
Science 25 June 2004: 1893.
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MICHAEL MAJERUS PROFILE:
In Defense of Darwin and a Former Icon of Evolution

Fiona Proffitt
Science 25 June 2004: 1894-1895.
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QUANTUM PHYSICS:
Elite Retreat Takes the Measure of a Weirdly Ordinary World

Adrian Cho
Science 25 June 2004: 1896-1897.
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ASTRONOMY:
Ultraviolet Astronomers Face Loss of Vision

Govert Schilling
Science 25 June 2004: 1899.
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Letters

This Week's Letters

Science 25 June 2004: 1903.
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 The Problems of Polio Eradication

Alan W. Dove
Science 25 June 2004: 1903.
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 Creating a Sustainable Future?

Bruce A. Wright and Thomas A. Okey
Science 25 June 2004: 1903.
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 Survivable Development

Bill Arledge
Science 25 June 2004: 1904.
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 What's Missing from Undergrad Science?

Bruce M. Jakosky
Science 25 June 2004: 1904.
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 NO Parkin in Parkinson's Disease

Jack R. Lancaster, Jr.;, Kenny K. K. Chung, Valina L. Dawson, and Ted M. Dawson
Science 25 June 2004: 1905.
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 CORRECTIONS AND CLARIFICATIONS

Science 25 June 2004: 1905.
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Books et al.

CHRONOBIOLOGY:
Life's Daily Beat

Eberhard Gwinner
Science 25 June 2004: 1906-1907.
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ENVIRONMENT:
The Natural Forces of Metaphor

Christopher Cokinos
Science 25 June 2004: 1907-1908.
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 Books Received

Science 25 June 2004: 1908.

Policy Forum

PUBLIC HEALTH:
Enhanced: A Global Response to AIDS: Lessons Learned, Next Steps

Peter Piot, Richard G. A. Feachem, Jong-wook Lee, and James D. Wolfensohn
Science 25 June 2004: 1909-1910.
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PUBLIC HEALTH:
Regulatory Challenges in Microbicide Development

Paul M. Coplan, Mark Mitchnick, and Zeda F. Rosenberg
Science 25 June 2004: 1911-1912.
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Perspectives

AIDS/HIV:
Developing an AIDS Vaccine: Need, Uncertainty, Hope

Emilio A. Emini and Wayne C. Koff
Science 25 June 2004: 1913-1914.
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ASTRONOMY:
The Short Spectacular Life of a Superstar

Gerry Gilmore
Science 25 June 2004: 1915-1916.
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BIOCHEMISTRY:
De Novo Design of an Enzyme

Reinhard Sterner and Franz X. Schmid
Science 25 June 2004: 1916-1917.
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MATERIAL SCIENCE:
Spinning Continuous Fibers for Nanotechnology

Yuris Dzenis
Science 25 June 2004: 1917-1919.
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OCEAN SCIENCE:
Hemispheric Asynchrony of Abrupt Climate Change

Jean Lynch-Stieglitz
Science 25 June 2004: 1919-1920.
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Review

Neuronal Oscillations in Cortical Networks

György Buzsáki and Andreas Draguhn
Science 25 June 2004: 1926-1929.
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Brevia

 DNA Methylation Is Independent of RNA Interference in Neurospora

Michael Freitag, Dong W. Lee, Gregory O. Kothe, Robert J. Pratt, Rodolfo Aramayo, and Eric U. Selker
Science 25 June 2004: 1939.
Although double-stranded RNA participates in gene silencing by DNA methylation in plants, it is not necessary in the filamentous fungus Neurospora. Full Text »|   PDF »|   Supporting Online Material »|  

Research Article

Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors

Qin Wang, Jiali Zhao, Ashley E. Brady, Jian Feng, Patrick B. Allen, Robert J. Lefkowitz, Paul Greengard, and Lee E. Limbird
Science 25 June 2004: 1940-1944.
A ubiquitous cellular protein controls a huge family of cell surface receptors for hormones and neurotransmitters by interfering with another regulator. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Reports

A Molecular Photodiode System That Can Switch Photocurrent Direction

Shiro Yasutomi, Tomoyuki Morita, Yukio Imanishi, and Shunsaku Kimura
Science 25 June 2004: 1944-1947.
A molecular photodiode formed by anchoring two helical peptides sensitive to different wavelengths of light conducts current in opposite directions depending on the wavelength used. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Discovery of a Compact Radio Component in the Center of Supernova 1986J

Michael F. Bietenholz, Norbert Bartel, and Michael P. Rupen
Science 25 June 2004: 1947-1949.
Published online 10 June 2004 [DOI: 10.1126/science.1099460] (in Science Express Reports)
Changes in the radio emissions from the core of Supernova 1986J, 20 years after its collapse, support the theoretical prediction that a black hole or neutron star is forming. Abstract »|   Full Text »|   PDF »|  

Earthquakes Beneath the Himalayas and Tibet: Evidence for Strong Lithospheric Mantle

Wang-Ping Chen and Zhaohui Yang
Science 25 June 2004: 1949-1952.
Earthquakes within Earth's upper mantle deep beneath the western Himalayas indicate that the mantle is unusually strong there. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Dynamics of Slow-Moving Landslides from Permanent Scatterer Analysis

George E. Hilley, Roland Bürgmann, Alessandro Ferretti, Fabrizio Novali, and Fabio Rocca
Science 25 June 2004: 1952-1955.
Ten years of satellite radar interferometry measurements reveal how several slow-moving landslides in California accelerated after heavy rains, especially during an El Niño year. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Abrupt Tropical Vegetation Response to Rapid Climate Changes

Konrad A. Hughen, Timothy I. Eglinton, Li Xu, and Matthew Makou
Science 25 June 2004: 1955-1959.
Published online 20 May 2004 [DOI: 10.1126/science.1092995] (in Science Express Reports)
Large, sudden changes in the vegetation of tropical South America occurred several decades after rapid climate shifts seen in the Northern Hemisphere during the last deglaciation. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Antarctic Timing of Surface Water Changes off Chile and Patagonian Ice Sheet Response

Frank Lamy, Jérôme Kaiser, Ulysses Ninnemann, Dierk Hebbeln, Helge W. Arz, and Joseph Stoner
Science 25 June 2004: 1959-1962.
A detailed climate record from a core in the southeast Pacific shows that sea surface temperatures there changed in concert with Antarctic temperatures over the past 50,000 years. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Activation of Transcription Factor NF-B Requires ELKS, an IB Kinase Regulatory Subunit

Jeanette L. Ducut Sigala, Virginie Bottero, David B. Young, Andrej Shevchenko, Frank Mercurio, and Inder M. Verma
Science 25 June 2004: 1963-1967.
A ubiquitous protein is shown to be essential for inflammation in human cells and could be a useful target for anti-inflammatory drugs. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Computational Design of a Biologically Active Enzyme

Mary A. Dwyer, Loren L. Looger, and Homme W. Hellinga
Science 25 June 2004: 1967-1971.
Rationally designed mutations convert a catalytically dead ribose binding protein into an active isomerase enzyme. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

RNAi-Independent Heterochromatin Nucleation by the Stress-Activated ATF/CREB Family Proteins

Songtao Jia, Ken-ichi Noma, and Shiv I. S. Grewal
Science 25 June 2004: 1971-1976.
DNA near centromeres of yeast can be silenced by two stress-related transcription factors, independent of RNA-related silencing. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Postnatal Refinement of Peripheral Olfactory Projections

Dong-Jing Zou, Paul Feinstein, Aimée L. Rivers, Glennis A. Mathews, Ann Kim, Charles A. Greer, Peter Mombaerts, and Stuart Firestein
Science 25 June 2004: 1976-1979.
Published online 3 June 2004 [DOI: 10.1126/science.1093468] (in Science Express Reports)
Normal maturation of the sense of smell requires that mice experience various odors during a critical period of development. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Regulation of Dendritic Protein Synthesis by Miniature Synaptic Events

Michael A. Sutton, Nicholas R. Wall, Girish N. Aakalu, and Erin M. Schuman
Science 25 June 2004: 1979-1983.
Low-level background synaptic events unexpectedly influence local protein synthesis in neuronal dendrites. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Deficit in Attachment Behavior in Mice Lacking the µ-Opioid Receptor Gene

Anna Moles, Brigitte L. Kieffer, and Francesca R. D'Amato
Science 25 June 2004: 1983-1986.
Mouse pups that lack a type of opioid receptor usually associated with pain and reward are less attached to their mothers than are normal pups. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Robust Temporal Coding in the Trigeminal System

Lauren M. Jones, Didier A. Depireux, Daniel J. Simons, and Asaf Keller
Science 25 June 2004: 1986-1989.
With each movement of a rat's whisker, corresponding neurons in the brain receive a stereotyped, precisely timed train of action potentials. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Layer-Specific Somatosensory Cortical Activation During Active Tactile Discrimination

David J. Krupa, Michael C. Wiest, Marshall G. Shuler, Mark Laubach, and Miguel A. L. Nicolelis
Science 25 June 2004: 1989-1992.
Brain activity elicited by passive movement of a rat's whiskers differs from that induced by the rat's own active use of whiskers in exploring its environment. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|