This Week in Science

Editor summaries of this week's papers.
Science 4 June 2004: 1409.
|Full Text »

Editorial:
The Obesity Epidemic

Philip Abelson and Donald Kennedy
Science 4 June 2004: 1413.
Summary »|   PDF »|  

Editors' Choice

Highlights of the recent literature.
Science 4 June 2004: 1415.
|Full Text »

NetWatch

Best of the Web in science.
Science 4 June 2004: 1421.
|Full Text »

 New Products

Science 4 June 2004: 1519.
PDF »|  

News of the Week

PUBLISHING:
U.S. Trade Policy Creates Confusion Over Co-Authorship

Yudhijit Bhattacharjee
Science 4 June 2004: 1422.
Summary »|   Full Text »|   PDF »|  

PLANETARY ORIGINS:
Youngest Extrasolar Planet Reported

Richard A. Kerr
Science 4 June 2004: 1423.
Summary »|   Full Text »|   PDF »|  

GENE THERAPY:
Side Effects Sideline Hemophilia Trial

Jocelyn Kaiser
Science 4 June 2004: 1423-1425.
Summary »|   Full Text »|   PDF »|  

PALEONTOLOGY:
Controversial Fossil Could Shed Light on Early Animals' Blueprint

Erik Stokstad
Science 4 June 2004: 1425.
Summary »|   Full Text »|   PDF »|  

GENOMICS:
TIGR Escapes Venter's Plan for Consolidation

Eliot Marshall
Science 4 June 2004: 1426.
Summary »|   Full Text »|   PDF »|  

PLANT GENOMICS:
Syngenta Donates 48,000 Mutant Arabidopsis Plants

Elizabeth Pennisi
Science 4 June 2004: 1426.
Summary »|   Full Text »|   PDF »|  

INTELLECTUAL PROPERTY:
NIH Weighs Demand to Force Sharing of AIDS Drug Patents

David Malakoff
Science 4 June 2004: 1427-1429.
Summary »|   Full Text »|   PDF »|  

DEVELOPMENT SPENDING:
Economists Rate Greenhouse Gas Curbs a Poor Investment

John Bohannon
Science 4 June 2004: 1429.
Summary »|   Full Text »|   PDF »|  

ScienceScope

Science 4 June 2004: 1425.
|Full Text »

Random Samples

Science 4 June 2004: 1441.
|Full Text »

News Focus

HIV/AIDS IN CHINA:
Poised for Takeoff?

Jon Cohen
Science 4 June 2004: 1430-1432.
Summary »|   Full Text »|   PDF »|  

HIV/AIDS IN CHINA:
A New Treatment Campaign, But With Limited Weapons

Jon Cohen
Science 4 June 2004: 1433.
Summary »|   Full Text »|   PDF »|  

HIV/AIDS IN CHINA:
Changing Course to Break the HIV-Heroin Connection

Jon Cohen
Science 4 June 2004: 1434-1435.
Summary »|   Full Text »|   PDF »|  

HIV/AIDS IN CHINA:
Vaccine Development With a Distinctly Chinese Flavor

Jon Cohen
Science 4 June 2004: 1437.
Summary »|   Full Text »|   PDF »|  

HIV/AIDS IN CHINA:
An Unsafe Practice Turned Blood Donors Into Victims

Jon Cohen
Science 4 June 2004: 1438-1439.
Summary »|   Full Text »|   PDF »|  

HIV/AIDS IN CHINA:
A Scoop of International Proportions

Jon Cohen
Science 4 June 2004: 1439.
Summary »|   Full Text »|   PDF »|  

Letters

This Week's Letters

Science 4 June 2004: 1445.
Summary »|   PDF »|  

 A Plea for DNA Banking

Vincent Savolainen and Gail Reeves
Science 4 June 2004: 1445.
Full Text »|   PDF »|  

 Setting Priorities for Genomic Research

Wade Berrettini, Laura Bierut, Thomas J Crowley, Joseph F. Cubells, Joseph Frascella, Joel Gelernter, John K. Hewitt, Mary Jeanne Kreek, Herb Lachman, Mark Leppert, Ming D. Li, Herb Lachman, Mark Leppert, Ming D. Li, Pamela Madden, Cindy Miner, Jonathan D. Pollock, Ovide Pomerleau, John P. Rice, Joni L. Rutter, David Shurtleff, Gary E. Swan, Jay A. Tischfield, Ming Tsuang, George R. Uhl, Michael Vanyukov, Nora D. Volkow, Kay Wanke;, Kathleen Ries Merikangas, and Neil Risch
Science 4 June 2004: 1445-1447.
Full Text »|   PDF »|  

 Questions About Disclosure

Carol J. Henry;, David Michaels, and Wendy Wagner
Science 4 June 2004: 1447-1449.
Full Text »|   PDF »|  

 Corrections and Clarifications

Science 4 June 2004: 1449.
Full Text »|   PDF »|  

Books et al.

COGNITIVE SCIENCE:
Programs of the Mind

Gary Marcus
Science 4 June 2004: 1450-1451.
Summary »|   Full Text »|   PDF »|  

NEUROSCIENCE:
PET Pictures

Bettyann Holtzmann Kevles
Science 4 June 2004: 1451.
Summary »|   Full Text »|   PDF »|  

 Books Received

Science 4 June 2004: 1451.

Policy Forum

SOCIOLOGY:
What If We Give a Census and No One Comes?

Kenneth Prewitt
Science 4 June 2004: 1452-1453.
Summary »|   Full Text »|   PDF »|  

Perspectives

NEUROSCIENCE:
Crossing the Midline

C. Geoffrey Woods
Science 4 June 2004: 1455-1456.
Summary »|   Full Text »|   PDF »|  

PHYSICS:
Enhanced: Ion Entanglement in Quantum Information Processing

D. G. Cory and T. F. Havel
Science 4 June 2004: 1456-1457.
Summary »|   Full Text »|   PDF »|  

MATERIALS SCIENCE:
Designer Nanotubes by Molecular Self-Assembly

Werner J. Blau and Alexander J. Fleming
Science 4 June 2004: 1457-1458.
Summary »|   Full Text »|   PDF »|  

CANCER:
A Bull's Eye for Targeted Lung Cancer Therapy

John D. Minna, Adi F. Gazdar, Stephen R. Sprang, and Joachim Herz
Science 4 June 2004: 1458-1461.
Summary »|   Full Text »|   PDF »|  

PLANT SCIENCES:
Yoda Would Be Proud: Valves for Land Plants

Fred D. Sack
Science 4 June 2004: 1461-1462.
Summary »|   Full Text »|   PDF »|  

Review

Challenges of Modeling Ocean Basin Ecosystems

Brad deYoung, Mike Heath, Francisco Werner, Fei Chai, Bernard Megrey, and Patrick Monfray
Science 4 June 2004: 1463-1466.
Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Brevia

 Odorant Receptors on Axon Termini in the Brain

G. Barnea, S. O'Donnell, F. Mancia, X. Sun, A. Nemes, M. Mendelsohn, and R. Axel
Science 4 June 2004: 1468.
Receptors that sense odor molecules in olfactory neurons are also found in the axons of these neurons, where they likely help direct connections to the brain. Full Text »|   PDF »|   Supporting Online Material »|  

Research Article

Bedout: A Possible End-Permian Impact Crater Offshore of Northwestern Australia

L. Becker, R. J. Poreda, A. R. Basu, K. O. Pope, T. M. Harrison, C. Nicholson, and R. Iasky
Science 4 June 2004: 1469-1476.
Published online 13 May 2004 [DOI: 10.1126/science.1093925] (in Science Express Research Articles)
Analysis of drill cores and geophysical data suggests that a buried impact crater formed near the end of the Permian lies northwest of Australia. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Reports

Toward Heisenberg-Limited Spectroscopy with Multiparticle Entangled States

D. Leibfried, M. D. Barrett, T. Schaetz, J. Britton, J. Chiaverini, W. M. Itano, J. D. Jost, C. Langer, and D. J. Wineland
Science 4 June 2004: 1476-1478.
Quantum entanglement of three ions allows improvement of the resolution of spectroscopy close to the limit set by the Heisenberg Uncertainty Principle. Abstract »|   Full Text »|   PDF »|  

Control and Measurement of Three-Qubit Entangled States

Christian F. Roos, Mark Riebe, Hartmut Häffner, Wolfgang Hänsel, Jan Benhelm, Gavin P. T. Lancaster, Christoph Becher, Ferdinand Schmidt-Kaler, and Rainer Blatt
Science 4 June 2004: 1478-1480.
The state of one entangled ion in a trap can be determined and manipulated without destroying the coherence of two other entangled ions, a necessary step for transferring information in a quantum computer. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Self-Assembled Hexa-peri-hexabenzocoronene Graphitic Nanotube

Jonathan P. Hill, Wusong Jin, Atsuko Kosaka, Takanori Fukushima, Hideki Ichihara, Takeshi Shimomura, Kohzo Ito, Tomihiro Hashizume, Noriyuki Ishii, and Takuzo Aida
Science 4 June 2004: 1481-1483.
A compound composed of fused benzene rings can be induced to form tubular structures, instead of the standard columnar or layered structures typical of such graphitic materials. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Increasing Ozone over the Atlantic Ocean

J. Lelieveld, J. van Aardenne, H. Fischer, M. de Reus, J. Williams, and P. Winkler
Science 4 June 2004: 1483-1487.
Published online 13 May 2004 [DOI: 10.1126/science.1096777] (in Science Express Reports)
Increased fossil and biomass fuel burning in Africa during the past 25 years has increased tropospheric ozone levels in the tropics and South Atlantic. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Atmospheric New Particle Formation Enhanced by Organic Acids

Renyi Zhang, Inseon Suh, Jun Zhao, Dan Zhang, Edward C. Fortner, Xuexi Tie, Luisa T. Molina, and Mario J. Molina
Science 4 June 2004: 1487-1490.
Organic acid pollution mixes with emitted sulfuric acid to help form sulfate aerosol particles that strongly influence atmospheric chemistry and regional and global climate. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

The Acquisition of Exogenous Algal Symbionts by an Octocoral After Bleaching

Cynthia L. Lewis and Mary Alice Coffroth
Science 4 June 2004: 1490-1492.
After losing their symbionts through environmental stress-induced bleaching, soft corals can acquire new algal residents from the seawater or through regrowth of resident algae. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Flexibility in Algal Endosymbioses Shapes Growth in Reef Corals

Angela F. Little, Madeleine J. H. van Oppen, and Bette L. Willis
Science 4 June 2004: 1492-1494.
Certain strains of algal endosymbionts accelerate the growth of their young stony corals hosts. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Stomatal Development and Pattern Controlled by a MAPKK Kinase

Dominique C. Bergmann, Wolfgang Lukowitz, and Chris R. Somerville
Science 4 June 2004: 1494-1497.
A protein that forms and organizes stomata, the pores that promote gas exchange in plants, is the same one that promotes the generation of other specialized cells in plants. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

J. Guillermo Paez, Pasi A. Jänne, Jeffrey C. Lee, Sean Tracy, Heidi Greulich, Stacey Gabriel, Paula Herman, Frederic J. Kaye, Neal Lindeman, Titus J. Boggon, Katsuhiko Naoki, Hidefumi Sasaki, Yoshitaka Fujii, Michael J. Eck, William R. Sellers, Bruce E. Johnson, and Matthew Meyerson
Science 4 June 2004: 1497-1500.
Published online 29 April 2004 [DOI: 10.1126/science.1099314] (in Science Express Reports)
Lung cancers that can be successfully treated with a new drug all have mutations in one type of receptor, a discovery that opens up new possibilities for personalized cancer therapy. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Regulation of an ATG7-beclin 1 Program of Autophagic Cell Death by Caspase-8

Li Yu, Ajjai Alva, Helen Su, Parmesh Dutt, Eric Freundt, Sarah Welsh, Eric H. Baehrecke, and Michael J. Lenardo
Science 4 June 2004: 1500-1502.
Published online 6 May 2004 [DOI: 10.1126/science.1096645] (in Science Express Reports)
Cell death can occur by autophagy (digestion of subcellular components within a living cell) through a pathway different from that used in apoptosis. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Roles of the Two Drosophila CRYPTOCHROME Structural Domains in Circadian Photoreception

Ania Busza, Myai Emery-Le, Michael Rosbash, and Patrick Emery
Science 4 June 2004: 1503-1506.
The photoreceptor for the circadian clock in flies acts by degrading itself and a transcription factor and is homologous to that for plants but senses light with a different region of the protein. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Crystal Structure of the Long-Chain Fatty Acid Transporter FadL

Bert van den Berg, Paul N. Black, William M. Clemons, Jr., and Tom A. Rapoport
Science 4 June 2004: 1506-1509.
Hydrophobic fatty acids move across bacterial membranes through a 14-stranded barrel-shaped transporter with a hatch that spontaneously opens to form a channel. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Mutations in a Human ROBO Gene Disrupt Hindbrain Axon Pathway Crossing and Morphogenesis

Joanna C. Jen, Wai-Man Chan, Thomas M. Bosley, Jijun Wan, Janai R. Carr, Udo Rüb, David Shattuck, Georges Salamon, Lili C. Kudo, Jing Ou, Doris D. M. Lin, Mustafa A. M. Salih, Tülay Kansu, Hesham al Dhalaan, Zayed al Zayed, David B. MacDonald, Bent Stigsby, Andreas Plaitakis, Emmanuel K. Dretakis, Irene Gottlob, Christina Pieh, Elias I. Traboulsi, Qing Wang, Lejin Wang, Caroline Andrews, Koki Yamada, Joseph L. Demer, Shaheen Karim, Jeffry R. Alger, Daniel H. Geschwind, Thomas Deller, Nancy L. Sicotte, Stanley F. Nelson, Robert W. Baloh, and Elizabeth C. Engle
Science 4 June 2004: 1509-1513.
Published online 22 April 2004 [DOI: 10.1126/science.1096437] (in Science Express Reports)
A mutation in a human gene similar to one that guides developing nerve fibers in animals causes a form of severe scoliosis and abnormal eye muscle control. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

A Microdomain for Protein Secretion in Gram-Positive Bacteria

Jason Rosch and Michael Caparon
Science 4 June 2004: 1513-1515.
Streptococcus pyogenes, the "flesh-eating" bacterium, secretes its toxins through a single specialized membrane region that contains all of the secretory proteins. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

A Process for Controlling Intracellular Bacterial Infections Induced by Membrane Injury

Deepannita Roy, David R. Liston, Vincent J. Idone, Anke Di, Deborah J. Nelson, Céline Pujol, James B. Bliska, Sabyasachi Chakrabarti, and Norma W. Andrews
Science 4 June 2004: 1515-1518.
When bacteria are engulfed by protective immune cells, they trigger a defense system in which the bacteria-containing vesicle fuses with the cellular compartment containing degradative enzymes. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|