Pulsars

The Strange and Twisted World of Pulsars

Linda Rowan and Robert Coontz
Science 23 April 2004: 531.
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News

The Pulsar Menagerie

Robert Irion
Science 23 April 2004: 532-533.
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Pulsars Surf the Cosmic Waves

Robert Irion
Science 23 April 2004: 533.
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Crushed by Magnetism

Robert Irion
Science 23 April 2004: 534-535.
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Reviews

The Physics of Neutron Stars

J. M. Lattimer and M. Prakash
Science 23 April 2004: 536-542.
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Observational Properties of Pulsars

R. N. Manchester
Science 23 April 2004: 542-546.
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Pulsars in Binary Systems: Probing Binary Stellar Evolution and General Relativity

Ingrid H. Stairs
Science 23 April 2004: 547-552.
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This Week in Science

Editor summaries of this week's papers.
Science 23 April 2004: 485.
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Editorial:
So Few Pulsars, So Few Females

S. Jocelyn Bell Burnell
Science 23 April 2004: 489.
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Editors' Choice

Highlights of the recent literature.
Science 23 April 2004: 491.
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NetWatch

Best of the Web in science.
Science 23 April 2004: 495.
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 New Products

Science 23 April 2004: 603.
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News of the Week

REGULATORY POLICY:
White House Softens Disputed Peer-Review Plan

Jocelyn Kaiser
Science 23 April 2004: 496-497.
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U.S. OCEAN SCIENCE:
Commission Urges Major Boost in Cash and Clout

David Malakoff
Science 23 April 2004: 496.
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SPACE SCIENCE:
NASA Backs Two Missions to Spot Promising Planets

Andrew Lawler
Science 23 April 2004: 497-499.
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AIDS MEETING:
Edict Limits U.S. Speakers at Bangkok Conference

Jennifer Couzin
Science 23 April 2004: 499-500.
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SCIENCE AND SECURITY:
Reports Examine Academe's Role in Keeping Secrets

David Malakoff
Science 23 April 2004: 500.
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REPRODUCTIVE BIOLOGY:
Japanese Scientists Create Fatherless Mouse

Gretchen Vogel
Science 23 April 2004: 501-503.
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PALEONTOLOGY:
New Biomarker Proposed for Earliest Life on Earth

Richard A. Kerr
Science 23 April 2004: 503.
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ScienceScope

Science 23 April 2004: 499.
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Random Samples

Science 23 April 2004: 514.
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News Focus

HIV/AIDS IN INDIA:
HIV/AIDS: India's Many Epidemics

Jon Cohen
Science 23 April 2004: 504-509.
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HIV/AIDS IN INDIA:
Sonagachi Sex Workers Stymie HIV

Jon Cohen
Science 23 April 2004: 506.
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HIV/AIDS IN INDIA:
The National AIDS Research Institute's Long Reach

Jon Cohen
Science 23 April 2004: 508.
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HIV/AIDS IN INDIA:
The Needle and the Damage Done

Jon Cohen
Science 23 April 2004: 509-512.
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HIV/AIDS IN INDIA:
Till Death Do Us Part

Jon Cohen
Science 23 April 2004: 513.
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Letters

This Week's Letters

Science 23 April 2003: 516.
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 The Postdoctoral Workforce

David Korn
Science 23 April 2004: 516.
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 Changing Job Expectations

Jonathan Adams
Science 23 April 2004: 516.
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 Language and Systems of Symbols

David Alexander;, Gordon Kane;, and David Premack
Science 23 April 2004: 516-518.
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 Teaching Quantitative Thinking

Shukdeb Sen
Science 23 April 2004: 518.
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 CORRECTIONS AND CLARIFICATIONS

Science 23 April 2004: 518.
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Books et al.

BEHAVIORAL ECOLOGY:
Why Animals Don't Lie

Nils Chr. Stenseth and Glenn-Peter Sætre
Science 23 April 2004: 519-520.
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BIOMECHANICS:
Life Among the Formulae of Physics

Julian F. V. Vincent
Science 23 April 2004: 520.
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 Books Received

Science 23 April 2004: 520.

Policy Forum

EDUCATION:
Scientific Teaching

Jo Handelsman, Diane Ebert-May, Robert Beichner, Peter Bruns, Amy Chang, Robert DeHaan, Jim Gentile, Sarah Lauffer, James Stewart, Shirley M. Tilghman, and William B. Wood
Science 23 April 2004: 521-522.
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Perspectives

NEUROSCIENCE:
Enhanced: Time Is Precious

Moshe Abeles
Science 23 April 2004: 523-524.
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PHYSICS:
Coupling Qubits by Waves on the Electron Sea

L. I. Glazman and R. C. Ashoori
Science 23 April 2004: 524-525.
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CELL BIOLOGY:
Cutting and Pasting Antigenic Peptides

Peter Cresswell
Science 23 April 2004: 525-527.
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COMPUTER SCIENCE:
Technological Networks and the Spread of Computer Viruses

Justin Balthrop, Stephanie Forrest, M. E. J. Newman, and Matthew M. Williamson
Science 23 April 2004: 527-529.
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IMMUNOLOGY:
CD8 and T Cell Memory

Sangwon V. Kim and Richard A. Flavell
Science 23 April 2004: 529-530.
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Brevia

 Radar Detection of Iapetus

Gregory J. Black, Donald B. Campbell, Lynn M. Carter, and Steven J. Ostro
Science 23 April 2004: 553.
One side of Saturn's moon Iapetus appears dark because of its thin surface coating, not because it has a different composition. Full Text »|   PDF »|  

 High Frequency of Mutations of the PIK3CA Gene in Human Cancers

Yardena Samuels, Zhenghe Wang, Alberto Bardelli, Natalie Silliman, Janine Ptak, Steve Szabo, Hai Yan, Adi Gazdar, Steven M. Powell, Gregory J. Riggins, James K. V. Willson, Sanford Markowitz, Kenneth W. Kinzler, Bert Vogelstein, and Victor E. Velculescu
Science 23 April 2004: 554.
Published online 11 March 2004 [DOI: 10.1126/science.1096502] (in Science Express Brevia)
A gene coding for a well-known lipid kinase is frequently mutated in human tumors, offering a new target for cancer diagnosis and therapy. Full Text »|   PDF »|   Supporting Online Material »|  

Research Articles

Decline of Subpolar North Atlantic Circulation During the 1990s

Sirpa Häkkinen and Peter B. Rhines
Science 23 April 2004: 555-559.
Published online 15 April 2004 [DOI: 10.1126/science.1094917] (in Science Express Research Articles)
Satellite and ocean observations show that circulation of the North Atlantic slowed during the 1990s, possibly as a result of global warming. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Synfire Chains and Cortical Songs: Temporal Modules of Cortical Activity

Yuji Ikegaya, Gloster Aaron, Rosa Cossart, Dmitriy Aronov, Ilan Lampl, David Ferster, and Rafael Yuste
Science 23 April 2004: 559-564.
Sequences of neural activity are repeated with high fidelity over the course of minutes in the cortex of the brain, in a sort of neuronal "song." Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Reports

Tunable Nonlocal Spin Control in a Coupled-Quantum Dot System

N. J. Craig, J. M. Taylor, E. A. Lester, C. M. Marcus, M. P. Hanson, and A. C. Gossard
Science 23 April 2004: 565-567.
Published online 25 March 2004 [DOI: 10.1126/science.1095452] (in Science Express Reports)
Adjustment of the number of electrons on one quantum dot can control the conductance of a second, remotely located one, providing a way to transmit quantum information. Abstract »|   Full Text »|   PDF »|  

Self-Assembly of Ordered, Robust, Three-Dimensional Gold Nanocrystal/Silica Arrays

Hongyou Fan, Kai Yang, Daniel M. Boye, Thomas Sigmon, Kevin J. Malloy, Huifang Xu, Gabriel P. López, and C. Jeffrey Brinker
Science 23 April 2004: 567-571.
Evaporation of a silica-organic emulsion allows suspended gold particles to order, rather than merely aggregate, forming structures with unusual electronic properties. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Probabilistic Integrated Assessment of "Dangerous" Climate Change

Michael D. Mastrandrea and Stephen H. Schneider
Science 23 April 2004: 571-575.
An analysis of uncertainties related to future climate and economics suggests that simple climate mitigation policies would reduce the risks of anthropogenic climate change. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Timing, Duration, and Transitions of the Last Interglacial Asian Monsoon

Daoxian Yuan, Hai Cheng, R. Lawrence Edwards, Carolyn A. Dykoski, Megan J. Kelly, Meiliang Zhang, Jiaming Qing, Yushi Lin, Yongjin Wang, Jiangyin Wu, Jeffery A. Dorale, Zhisheng An, and Yanjun Cai
Science 23 April 2004: 575-578.
A stalagmite from China reveals that the strength of the Asian Monsoon varied greatly over the past 160,000 years, increasing abruptly as the last interglacial period began. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Early Life Recorded in Archean Pillow Lavas

Harald Furnes, Neil R. Banerjee, Karlis Muehlenbachs, Hubert Staudigel, and Maarten de Wit
Science 23 April 2004: 578-581.
Ancient microbes colonized, pitted, and altered basalt that erupted on the ocean floor 3.5 billion years ago. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

The Fine-Scale Structure of Recombination Rate Variation in the Human Genome

Gilean A. T. McVean, Simon R. Myers, Sarah Hunt, Panos Deloukas, David R. Bentley, and Peter Donnelly
Science 23 April 2004: 581-584.
Patterns of sequence variation show that half of the genetic recombination within the human genome occurs in only 10% of the sequence. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

The Rise of the Rhizosolenid Diatoms

Jaap S. Sinninghe Damsté, Gerard Muyzer, Ben Abbas, Sebastiaan W. Rampen, Guillaume Massé, W. Guy Allard, Simon T. Belt, Jean-Michel Robert, Steven J. Rowland, J. Michael Moldowan, Silvana M. Barbanti, Frederick J. Fago, Peter Denisevich, Jeremy Dahl, Luiz A. F. Trindade, and Stefan Schouten
Science 23 April 2004: 584-587.
A characteristic alkene marker preserved in ancient oil shows that certain groups of diatoms arose 91.5 million years ago, implying rapid evolution of this dominant phytoplankton group. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

An Antigenic Peptide Produced by Peptide Splicing in the Proteasome

Nathalie Vigneron, Vincent Stroobant, Jacques Chapiro, Annie Ooms, Gérard Degiovanni, Sandra Morel, Pierre van der Bruggen, Thierry Boon, and Benoît J. Van den Eynde
Science 23 April 2004: 587-590.
Published online 4 March 2004 [DOI: 10.1126/science.1095522] (in Science Express Reports)
The organelle that degrades proteins can also splice pieces of protein together to form an immune-reactive antigen. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

CD8-Mediated Survival and Differentiation of CD8 Memory T Cell Precursors

Loui T. Madakamutil, Urs Christen, Christopher J. Lena, Yiran Wang-Zhu, Antoine Attinger, Monisha Sundarrajan, Wilfried Ellmeier, Matthias G. von Herrath, Peter Jensen, Dan R. Littman, and Hilde Cheroutre
Science 23 April 2004: 590-593.
A subset of immune cells activated by an antigen are marked by an unusual cell-surface receptor, allowing them to persist and confer future immunity to that antigen. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

MicroRNA-Directed Cleavage of HOXB8 mRNA

Soraya Yekta, I-hung Shih, and David P. Bartel
Science 23 April 2004: 594-596.
A microRNA is implicated in the regulation of mammalian HOX genes. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Regeneration of Peroxiredoxins by p53-Regulated Sestrins, Homologs of Bacterial AhpD

Andrei V. Budanov, Anna A. Sablina, Elena Feinstein, Eugene V. Koonin, and Peter M. Chumakov
Science 23 April 2004: 596-600.
A cysteine sulfinyl reductase enzyme restores the cell's antioxidant defenses by activating an inactive antioxidant. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Curcumin, a Major Constituent of Turmeric, Corrects Cystic Fibrosis Defects

Marie E. Egan, Marilyn Pearson, Scott A. Weiner, Vanathy Rajendran, Daniel Rubin, Judith Glöckner-Pagel, Susan Canny, Kai Du, Gergely L. Lukacs, and Michael J. Caplan
Science 23 April 2004: 600-602.
A common Indian spice can correct defects in mice that have a cystic fibrosis-like disease, probably by allowing an abnormal protein to reach the cell surface and escape entrapment within the cell. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Technical Comments

 Comment on "High Deleterious Genomic Mutation Rate in Stationary Phase of Escherichia coli"

J. Arjan G. M. de Visser and Daniel E. Rozen
Science 23 April 2004: 518.
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 Response to Comment on "High Deleterious Genomic Mutation Rate in Stationary Phase of Escherichia coli"

Laurence Loewe
Science 23 April 2004: 518.
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