Drug Discovery

Rethinking Drug Discovery

Phil Szuromi, Valda Vinson, and Eliot Marshall
Science 19 March 2004: 1795.
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News

Surviving the Blockbuster Syndrome

Robert F. Service
Science 19 March 2004: 1796-1799.
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Orphan Drugs of the Future?

Robert F. Service
Science 19 March 2004: 1798.
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Viewpoints

Organic Chemistry in Drug Discovery

Malcolm MacCoss and Thomas A. Baillie
Science 19 March 2004: 1810-1813.
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Drug Delivery Systems: Entering the Mainstream

Theresa M. Allen and Pieter R. Cullis
Science 19 March 2004: 1818-1822.
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Reviews

Protein Kinase Inhibitors: Insights into Drug Design from Structure

Martin E. M. Noble, Jane A. Endicott, and Louise N. Johnson
Science 19 March 2004: 1800-1805.
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Polyketide and Nonribosomal Peptide Antibiotics: Modularity and Versatility

Christopher T. Walsh
Science 19 March 2004: 1805-1810.
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The Many Roles of Computation in Drug Discovery

William L. Jorgensen
Science 19 March 2004: 1813-1818.
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This Week in Science

Editor summaries of this week's papers.
Science 19 March 2004: 1725.
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Editorial:
Drug Discovery

Donald Kennedy
Science 19 March 2004: 1729.
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Editors' Choice

Highlights of the recent literature.
Science 19 March 2004: 1731.
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NetWatch

Best of the Web in science.
Science 19 March 2004: 1741.
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 NEW PRODUCTS

Science 19 March 2004: 1885.

News of the Week

U.S. TRADE POLICY:
Editing Ban to Be Eased, But Cuban Travel Blocked

Yudhijit Bhattacharjee
Science 19 March 2004: 1742.
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TEXAS BIOTERROR CASE:
Butler Gets 2 Years for Mishandling Plague Samples

David Malakoff and Kerry Drennan
Science 19 March 2004: 1743-1745.
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PLANETARY SCIENCE:
Far-Out Ice World

Robert Irion
Science 19 March 2004: 1743.
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ASTRONOMY:
Academy, GAO to Study Possible Robotic Hubble Mission

Andrew Lawler
Science 19 March 2004: 1745.
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JAPAN:
Older Scientists Win Majority of Funding

Dennis Normile
Science 19 March 2004: 1746.
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PARTICLE PHYSICS:
Gamma Rays Spotlight a Dark Horse for Dark Matter

Charles Seife
Science 19 March 2004: 1746.
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ECOLOGY:
Naturalists' Surveys Show That British Butterflies Are Going, Going ...

Elizabeth Pennisi
Science 19 March 2004: 1747.
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CONFLICT OF INTEREST:
Varmus Backs Some Limits on NIH's Consulting Policy

Jocelyn Kaiser
Science 19 March 2004: 1749.
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FRENCH PROTESTS:
Government Dangles Fresh Carrots to Dispirited Scientific Community

Barbara Casassus
Science 19 March 2004: 1749.
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ScienceScope

Science 19 March 2004: 1745.
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Random Samples

Science 19 March 2004: 1761.
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News Focus

ASTRONOMY:
Surveys Scour the Cosmic Deep

Robert Irion
Science 19 March 2004: 1750-1752.
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ECOLOGY:
A Bid to Save the 'Galápagos of the Indian Ocean'

Eva Sohlman
Science 19 March 2004: 1753.
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GENOMIC MEDICINE:
Gene Expression Tests Foretell Breast Cancer's Future

Ken Garber
Science 19 March 2004: 1754-1755.
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INTELLECTUAL PROPERTY:
NIH Roils Academe With Advice on Licensing DNA Patents

David Malakoff
Science 19 March 2004: 1757-1758.
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INTELLECTUAL PROPERTY:
Most Academics Eschewing Patents?

David Malakoff
Science 19 March 2004: 1757.
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SCIENTIFIC LIVES:
Reflected Glory: Life With a Nobelist Parent

Giselle Weiss
Science 19 March 2004: 1758-1759.
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Letters

This Week's Letters

Science 19 March 2004: 1765.
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 The Difficulties of Defining the Term "GM"

Paul Grun;, Tim Ramsay;, and Nina Fedoroff
Science 19 March 2004: 1765-1769.
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 "Physics First" and High School Teachers

Ahren Sadoff
Science 19 March 2004: 1769.
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 Research on Contraceptives

Sharyl J. Nass and Jerome F. Strauss, III
Science 19 March 2004: 1769-1771.
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 CORRECTIONS AND CLARIFICATIONS

Science 19 March 2004: 1771.
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Books et al.

NUCLEAR WARFARE:
Measuring the Unthinkable

Janne E. Nolan
Science 19 March 2004: 1772-1773.
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 Browsings

Science 19 March 2004: 1773.
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DEVELOPMENTAL BIOLOGY:
Nota Bene: God Bless Us, Every One

Monique Martineau
Science 19 March 2004: 1774.
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 Books Received

Science 19 March 2004: 1774.

Policy Forum

SCIENCE AND GOVERNMENT:
An International Framework to Promote Access to Data

Peter Arzberger, Peter Schroeder, Anne Beaulieu, Geof Bowker, Kathleen Casey, Leif Laaksonen, David Moorman, Paul Uhlir, and Paul Wouters
Science 19 March 2004: 1777-1778.
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Perspectives

EVOLUTION:
Parallel Evolution Is in the Genes

Hopi E. Hoekstra and Trevor Price
Science 19 March 2004: 1779-1781.
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CLIMATE:
Society and Sea Level Rise

Orrin H. Pilkey and J. Andrew G. Cooper
Science 19 March 2004: 1781-1782.
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BIOCHEMISTRY:
Water Photolysis in Biology

A. W. Rutherford and A. Boussac
Science 19 March 2004: 1782-1784.
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COMPUTERS AND MATHEMATICS:
Quantum Channel Capacities

Charles H. Bennett and Peter W. Shor
Science 19 March 2004: 1784-1787.
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VIROLOGY:
Enhanced: 1918 and All That

Edward C. Holmes
Science 19 March 2004: 1787-1788.
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GEOPHYSICS:
Rupture in the Laboratory

Mitiyasu Ohnaka
Science 19 March 2004: 1788-1789.
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Brevia

 Inhibition of Hepatitis B Virus Replication by APOBEC3G

Priscilla Turelli, Bastien Mangeat, Stephanie Jost, Sandrine Vianin, and Didier Trono
Science 19 March 2004: 1829.
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Research Articles

Architecture of the Photosynthetic Oxygen-Evolving Center

Kristina N. Ferreira, Tina M. Iverson, Karim Maghlaoui, James Barber, and So Iwata
Science 19 March 2004: 1831-1838.
Published online 5 February 2004 [DOI: 10.1126/science.1093087] (in Science Express Research Articles)
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The Structure and Receptor Binding Properties of the 1918 Influenza Hemagglutinin

S. J. Gamblin, L. F. Haire, R. J. Russell, D. J. Stevens, B. Xiao, Y. Ha, N. Vasisht, D. A. Steinhauer, R. S. Daniels, A. Elliot, D. C. Wiley, and J. J. Skehel
Science 19 March 2004: 1838-1842.
Published online 5 February 2004 [DOI: 10.1126/science.1093155] (in Science Express Research Articles)
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Reports

Optical Frequency Synthesis and Comparison with Uncertainty at the 10^-19 Level

Long-Sheng Ma, Zhiyi Bi, Albrecht Bartels, Lennart Robertsson, Massimo Zucco, Robert S. Windeler, Guido Wilpers, Chris Oates, Leo Hollberg, and Scott A. Diddams
Science 19 March 2004: 1843-1845.
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A Molecular Elevator

Jovica D. Badjic, Vincenzo Balzani, Alberto Credi, Serena Silvi, and J. Fraser Stoddart
Science 19 March 2004: 1845-1849.
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Electrical or Photocontrol of the Rotary Motion of a Metallacarborane

M. Frederick Hawthorne, Jeffrey I. Zink, Johnny M. Skelton, Michael J. Bayer, Chris Liu, Ester Livshits, Roi Baer, and Daniel Neuhauser
Science 19 March 2004: 1849-1851.
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Directional Dynamics in the Photodissociation of Oriented Molecules

T. Peter Rakitzis, Alrik J. van den Brom, and Maurice H. M. Janssen
Science 19 March 2004: 1852-1854.
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On the Cause of the 1930s Dust Bowl

Siegfried D. Schubert, Max J. Suarez, Philip J. Pegion, Randal D. Koster, and Julio T. Bacmeister
Science 19 March 2004: 1855-1859.
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Laboratory Earthquakes: The Sub-Rayleigh-to-Supershear Rupture Transition

Kaiwen Xia, Ares J. Rosakis, and Hiroo Kanamori
Science 19 March 2004: 1859-1861.
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Stathmin-Tubulin Interaction Gradients in Motile and Mitotic Cells

Philipp Niethammer, Philippe Bastiaens, and Eric Karsenti
Science 19 March 2004: 1862-1866.
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Structure of the Uncleaved Human H1 Hemagglutinin from the Extinct 1918 Influenza Virus

James Stevens, Adam L. Corper, Christopher F. Basler, Jeffery K. Taubenberger, Peter Palese, and Ian A. Wilson
Science 19 March 2004: 1866-1870.
Published online 5 February 2004 [DOI: 10.1126/science.1093373] (in Science Express Reports)
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Conserved Genetic Basis of a Quantitative Plumage Trait Involved in Mate Choice

Nicholas I. Mundy, Nichola S. Badcock, Tom Hart, Kim Scribner, Kirstin Janssen, and Nicola J. Nadeau
Science 19 March 2004: 1870-1873.
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Genetic Basis of Natural Variation in D. melanogaster Antibacterial Immunity

Brian P. Lazzaro, Bonnielin K. Sceurman, and Andrew G. Clark
Science 19 March 2004: 1873-1876.
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Impact of Nitrogen Deposition on the Species Richness of Grasslands

Carly J. Stevens, Nancy B. Dise, J. Owen Mountford, and David J. Gowing
Science 19 March 2004: 1876-1879.
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Comparative Losses of British Butterflies, Birds, and Plants and the Global Extinction Crisis

J. A. Thomas, M. G. Telfer, D. B. Roy, C. D. Preston, J. J. D. Greenwood, J. Asher, R. Fox, R. T. Clarke, and J. H. Lawton
Science 19 March 2004: 1879-1881.
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Technical Comments

 Comment on "Contributions of Anthropogenic and Natural Forcing to Recent Tropopause Height Changes"

Roger A. Pielke, Sr. and Thomas N. Chase
Science 19 March 2004: 1771.
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 Response to Comment on "Contributions of Anthropogenic and Natural Forcing to Recent Tropopause Height Changes"

B. D. Santer, M. F. Wehner, T. M. L. Wigley, R. Sausen, G. A. Meehl, K. E. Taylor, C. Ammann, J. Arblaster, W. M. Washington, J. S. Boyle, and W. Brüggemann
Science 19 March 2004: 1771.
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