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Cover Figure


COVER The inhibitor Gleevec bound to the catalytic domain of Abl tyrosine kinase, as rendered by the program Aesop from coordinates in the Protein Data Bank. A special section, along with associated online material, describes how new technologies are being applied to overcome the challenges of drug discovery. 1795. [Image: M. Noble et al.]

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Science. ISSN 0036-8075 (print), 1095-9203 (online)