This Week in Science

Editor summaries of this week's papers.
Science 20 February 2004: 1101.
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Editorial:
Supply Without Demand

Donald Kennedy, Jim Austin, Kirstie Urquhart, and Crispin Taylor
Science 20 February 2004: 1105.
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Editors' Choice

Highlights of the recent literature.
Science 20 February 2004: 1106.
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NetWatch

Best of the Web in science.
Science 20 February 2004: 1115.
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 NEW PRODUCTS

Science 20 February 2004: 1211.

News of the Week

NATIONAL SCIENCE FOUNDATION:
Colwell Steps Down, Bement Named Acting Director

Jeffrey Mervis
Science 20 February 2004: 1116-1117.
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NATIONAL SCIENCE FOUNDATION:
NIST Struggles to Escape the Knife

David Malakoff
Science 20 February 2004: 1116.
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BIOMEDICAL RESEARCH:
MRC Gets Flexible and Clinical in Funding Overhaul

Fiona Proffitt
Science 20 February 2004: 1117.
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QUANTUM PHYSICS:
Big, Hot Molecules Bridge the Gap Between Normal and Surreal

Charles Seife
Science 20 February 2004: 1119.
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NEUROSCIENCE:
Imaging Studies Show How Brain Thinks About Pain

Constance Holden
Science 20 February 2004: 1121.
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EMERGING INFECTIOUS DISEASES:
Nipah Virus (or a Cousin) Strikes Again

Martin Enserink
Science 20 February 2004: 1121.
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2004 ANNUAL MEETING:
Science in Seattle

Science 20 February 2004: 1122.
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2004 ANNUAL MEETING:
RNA Rules Metabolite Production

Jennifer Couzin
Science 20 February 2004: 1122.
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2004 ANNUAL MEETING:
Batteries Powered to Order

Robert F. Service
Science 20 February 2004: 1122.
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2004 ANNUAL MEETING:
Science at the Extremes?

Jeffrey Mervis
Science 20 February 2004: 1123.
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2004 ANNUAL MEETING:
Oceans Policy Is In for an Overhaul

Jay Withgott
Science 20 February 2004: 1123.
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ScienceScope

Science 20 February 2004: 1119.
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Random Samples

Science 20 February 2004: 1134.
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News Focus

WATER RESOURCES:
As the West Goes Dry

Robert F. Service
Science 20 February 2004: 1124-1127.
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BEHAVIORAL EVOLUTION:
The Evolution of the Golden Rule

Gretchen Vogel
Science 20 February 2004: 1128-1131.
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MIGUEL NICOLELIS PROFILE:
Brazil Institute Charts a New Hemisphere for Neuroscience

Marcia L. Triunfol and Jeffrey Mervis
Science 20 February 2004: 1131-1132.
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E.T. SEARCH:
No Din of Alien Chatter in Our Neighborhood

Richard A. Kerr
Science 20 February 2004: 1133.
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Letters

This Week's Letters

Science 20 February 2004: 1136.
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 Forensic Science and Academic Science

Christopher S. Palenik and Samuel J. Palenik
Science 20 February 2004: 1136.
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 More on Molecular Electronics

James R. Heath, J. Fraser Stoddart, R. Stanley Williams;, Edwin A. Chandross;, Paul S. Weiss;, and Robert Servic
Science 20 February 2004: 1136-1137.
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 International Agricultural Research

Norman E. Borlaug
Science 20 February 2004: 1137-1138.
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 CORRECTIONS AND CLARIFICATIONS

Science 20 February 2004: 1138.
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Books et al.

ANIMAL BEHAVIOR:
Biography of a Brilliant Birdwatcher

Johan J. Bolhuis
Science 20 February 2004: 1140-1141.
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IMMUNOLOGY:
Danger in Wonderland

Matthew L. Albert
Science 20 February 2004: 1141.
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 Books Received

Science 20 February 2004: 1141.

Policy Forum

BIOETHICS:
Is Biomedical Research Too Dangerous to Pursue?

Arthur Caplan
Science 20 February 2004: 1142.
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Perspectives

ASTRONOMY:
Enhanced: Double Pulsar Jackpot

Edward P. J. van den Heuvel
Science 20 February 2004: 1143-1144.
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NEUROSCIENCE:
The Where and When of Intention

David M. Eagleman
Science 20 February 2004: 1144-1146.
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CHEMISTRY:
Ions at the Air/Water Interface

Bruce C. Garrett
Science 20 February 2004: 1146-1147.
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MOLECULAR BIOLOGY:
Filling Gaps in Genome Organization

Artyom A. Alekseyenko and Mitzi I. Kuroda
Science 20 February 2004: 1148-1149.
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BIOMEDICINE:
Will the Real Cholesterol Transporter Please Stand Up

Eric L. Klett and Shailesh B. Patel
Science 20 February 2004: 1149-1150.
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Brevia

 Prebiotic Amino Acids as Asymmetric Catalysts

Sandra Pizzarello and Arthur L. Weber
Science 20 February 2004: 1151.
Amino acid enantiomers found in excess in some meteorites can transfer their chirality to sugars, which in turn can reform chiral amino acids. Full Text »|   PDF »|   Supporting Online Material »|  

Research Articles

A Double-Pulsar System: A Rare Laboratory for Relativistic Gravity and Plasma Physics

A. G. Lyne, M. Burgay, M. Kramer, A. Possenti, R.N. Manchester, F. Camilo, M. A. McLaughlin, D. R. Lorimer, N. D'Amico, B. C. Joshi, J. Reynolds, and P. C. C. Freire
Science 20 February 2004: 1153-1157.
Published online 8 January 2004 [DOI: 10.1126/science.1094645] (in Science Express Research Articles)
Two pulsars that orbit each other rapidly, one oscillating with a period of 2.8 seconds and the other every 23 milliseconds, allow observation of relativistic effects. Abstract »|   Full Text »|   PDF »|  

Empathy for Pain Involves the Affective but not Sensory Components of Pain

Tania Singer, Ben Seymour, John O'Doherty, Holger Kaube, Raymond J. Dolan, and Chris D. Frith
Science 20 February 2004: 1157-1162.
The subjective experience of pain and the underlying brain activity are enhanced by feeling empathy for another's pain, and diminished by administration of a placebo. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain

Tor D. Wager, James K. Rilling, Edward E. Smith, Alex Sokolik, Kenneth L. Casey, Richard J. Davidson, Stephen M. Kosslyn, Robert M. Rose, and Jonathan D. Cohen
Science 20 February 2004: 1162-1167.
The subjective experience of pain and the underlying brain activity are enhanced by feeling empathy for another's pain, and diminished by administration of a placebo. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Reports

Fragmentation in Massive Star Formation

Henrik Beuther and Peter Schilke
Science 20 February 2004: 1167-1169.
Observation of incipient star formation shows that massive stars, like smaller ones, form by coalescence of distributed gas and dust around a core. Abstract »|   Full Text »|   PDF »|  

Direct Measurement of Energy Thresholds to Conformational Isomerization in Tryptamine

Brian C. Dian, Jasper R. Clarkson, and Timothy S. Zwier
Science 20 February 2004: 1169-1173.
The energy needed to twist a metabolically active biomolecule is mapped, showing that its conformation depends upon the rotation angles of two internal bonds. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Formation of Secondary Organic Aerosols Through Photooxidation of Isoprene

Magda Claeys, Bim Graham, Gyorgy Vas, Wu Wang, Reinhilde Vermeylen, Vlada Pashynska, Jan Cafmeyer, Pascal Guyon, Meinrat O. Andreae, Paulo Artaxo, and Willy Maenhaut
Science 20 February 2004: 1173-1176.
Newly observed organic compounds in tropical air show that photooxidation of isoprene, commonly released by vegetation, is an important global source of derived organic aerosols. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Repeating Seismic Events in China

David P. Schaff and Paul G. Richards
Science 20 February 2004: 1176-1178.
Correlation of seismograms from 14,000 earthquakes in China shows that about 10% consisted of two or more quakes with the same size and dynamics, closely spaced in time. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Regulation of Cell Migration by the C2 Domain of the Tumor Suppressor PTEN

Myrto Raftopoulou, Sandrine Etienne-Manneville, Annette Self, Sarah Nicholls, and Alan Hall
Science 20 February 2004: 1179-1181.
When a tumor suppressor loses the ability to dephosphorylate itself, cells can migrate freely, possibly explaining metastases. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Recruitment and Spreading of the C. elegans Dosage Compensation Complex Along X Chromosomes

Györgyi Csankovszki, Patrick McDonel, and Barbara J. Meyer
Science 20 February 2004: 1182-1185.
In C. elegans, discrete regions of the X chromosome recruit a protein complex that first silences nearby genes, after which silencing spreads throughout the chromosome. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

An Engineered Pathway for the Formation of Protein Disulfide Bonds

Lluis Masip, Jonathan L. Pan, Suranjana Haldar, James E. Penner-Hahn, Matthew P. DeLisa, George Georgiou, James C. A. Bardwell, and Jean-François Collet
Science 20 February 2004: 1185-1189.
Under evolutionary pressure, in a test tube, an E. coli enzyme can acquire an iron-sulfide cluster, and thus the ability to dimerize and catalyze disulfide bond formation. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

The Structure of a Mycobacterial Outer-Membrane Channel

Michael Faller, Michael Niederweis, and Georg E. Schulz
Science 20 February 2004: 1189-1192.
The low-permeability pore that accounts for the relative insensitivity of tuberculosis bacteria to antibiotics is shaped like a goblet, with the mouth pointing outward. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Use of CD134 As a Primary Receptor by the Feline Immunodeficiency Virus

Masayuki Shimojima, Takayuki Miyazawa, Yasuhiro Ikeda, Elizabeth L. McMonagle, Hayley Haining, Hiroomi Akashi, Yasuhiro Takeuchi, Margaret J. Hosie, and Brian J. Willett
Science 20 February 2004: 1192-1195.
Feline immunodeficiency virus, which causes an AIDS-like disease in cats, infects immune cells via CD134 rather than CD4, the receptor used by HIV. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Regulation of Fasted Blood Glucose by Resistin

Ronadip R. Banerjee, Shamina M. Rangwala, Jennifer S. Shapiro, A. Sophie Rich, Ben Rhoades, Yong Qi, Juan Wang, Michael W. Rajala, Alessandro Pocai, Phillipp E. Scherer, Claire M. Steppan, Rexford S. Ahima, Silvana Obici, Luciano Rossetti, and Mitchell A. Lazar
Science 20 February 2004: 1195-1198.
Experiments in mice indicate that the fat-derived hormone resistin may contribute to the increased risk of hyperglycemia and type 2 diabetes associated with obesity. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Gene Targeting in Stem Cells from Individuals with Osteogenesis Imperfecta

Joel R. Chamberlain, Ulrike Schwarze, Pei-Rong Wang, Roli K. Hirata, Kurt D. Hankenson, James M. Pace, Robert A. Underwood, Kit M. Song, Michael Sussman, Peter H. Byers, and David W. Russell
Science 20 February 2004: 1198-1201.
Stem cells from patients with a genetic bone disease can be partially repaired by gene targeting, and can generate new bone when implanted into mice. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Niemann-Pick C1 Like 1 Protein Is Critical for Intestinal Cholesterol Absorption

Scott W. Altmann, Harry R. Davis, Jr., Li-ji Zhu, Xiaorui Yao, Lizbeth M. Hoos, Glen Tetzloff, Sai Prasad N. Iyer, Maureen Maguire, Andrei Golovko, Ming Zeng, Luquan Wang, Nicholas Murgolo, and Michael P. Graziano
Science 20 February 2004: 1201-1204.
The identification of a protein involved in the absorption of dietary cholesterol from the intestine may lead to new cholesterol-lowering therapies. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Nervy Links Protein Kinase A to Plexin-Mediated Semaphorin Repulsion

Jonathan R. Terman and Alex L. Kolodkin
Science 20 February 2004: 1204-1207.
A Drosophila protein links intracellular and extracellular signaling pathways that guide growing nerve axons away from certain regions. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|  

Attention to Intention

Hakwan C. Lau, Robert D. Rogers, Patrick Haggard, and Richard E. Passingham
Science 20 February 2004: 1208-1210.
Formulation of an intent to move a body part is accompanied by an increase in activity in the connections between the prefrontal cortex and a brain region involved in motor control. Abstract »|   Full Text »|   PDF »|   Supporting Online Material »|