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Science Signaling

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About the Cover

Cover Figure


COVER Pattern of light generated by a "zero-mode" waveguide, a 50-nm hole in a thin aluminum film. Such a waveguide enables observations of single molecules within zeptoliter optical volumes. As described on page 682, single molecules of a DNA polymerase enzyme could be seen to incorporate fluorescent nucleotides, as shown by the cartoon. [Illustration: K. Hodgson]

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Science. ISSN 0036-8075 (print), 1095-9203 (online)