COVER The crystal structure of BRCA2, a protein defective in hereditary breast cancer, reveals domains similar to those found in proteins that bind to DNA. The ability to bind DNA, confirmed by the structure of a BRCA2-DNA (cyan bases) complex, implicates BRCA2 in binding the DNA substrates (blue ribbons) involved in homologous recombination-mediated DNA repair. 1837 [Image: H. Yang et al.]

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