COVER Crystal structure of the multidrug resistance ABC transporter homolog MsbA from Escherichia coli as viewed from the plane of the lipid bilayer. This class of integral membrane proteins transports hydrophobic molecules such as lipids and drugs across the cell membrane bilayer. The structure of MsbA reveals three domains, which include the transmembrane (red), intracellular (dark blue), and nucleotide-binding (teal) domains. The structure can help elucidate the mechanism underlying multidrug resistance in the treatment of cancer and infectious diseases. 1793 [Image: G. Chang and C. B. Roth]

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