COVER Crystal structure of reduced carbon monoxide dehydrogenase from the anaerobic hydrogenogenic bacterium Carboxydothermus hydrogenoformans (electron micrograph in the background), showing the homodimeric enzyme (subunits in blue and yellow). At lower right, the [Ni-4Fe-5S] active-site cluster is shown; the substrate channel is in green, and nickel, iron, and sulfur atoms are in blue, red, and yellow, respectively. 1281 [Adapted from Figs. 1, 3, and 4 of Dobbek et al.]

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