COVER The adult skeleton is a highly dynamic organ--old bone is continually being destroyed and replaced with new bone. The cellular mechanisms that control this remodeling and new strategies for repairing broken or diseased bone are discussed in a special section beginning on page 1497. The micrograph shows a mouse bone stained with calcein, a fluorescent dye that is incorporated at sites of newly synthesized bone and can be used to measure the rate of bone formation. [Image: M. A. Amling]

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