Drug Discovery

An Information Revolution

Julia Uppenbrink and Jeffrey Mervis
Science 17 March 2000: 1951.
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News

When Pharma Merges, R&D Is the Dowry

Bruce Agnew
Science 17 March 2000: 1952-1953.
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Structural Genomics Offers High-Speed Look at Proteins

Robert F. Service
Science 17 March 2000: 1954-1956.
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Early Successes Hint at Big Payoff, But the Road to New Drugs Is Long

Robert F. Service
Science 17 March 2000: 1955.
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Malaria Researchers Wait for Industry to Join Fight

Martin Enserink
Science 17 March 2000: 1956-1958.
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U.S., Europe, Japan Look to Speed Up Drug Reviews

Dennis Normile and Eliot Marshall
Science 17 March 2000: 1958-1959.
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Viewpoints

Genomic Medicine and the Future of Health Care

Chris Sander
Science 17 March 2000: 1977-1978.
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The Global Drug Gap

Michael R. Reich
Science 17 March 2000: 1979-1981.
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Reviews

Drug Discovery: A Historical Perspective

Jürgen Drews
Science 17 March 2000: 1960-1964.
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Target-Oriented and Diversity-Oriented Organic Synthesis in Drug Discovery

Stuart L. Schreiber
Science 17 March 2000: 1964-1969.
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Mechanism-Based Target Identification and Drug Discovery in Cancer Research

Jackson B. Gibbs
Science 17 March 2000: 1969-1973.
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Harnessing the Power of the Genome in the Search for New Antibiotics

John Rosamond and Aileen Allsop
Science 17 March 2000: 1973-1976.
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This Week in Science

Editor summaries of this week's papers.
Science 17 March 2000: 1885.
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 Editorial:
Too Much of A Good Thing?

Floyd E. Bloom
Science 17 March 2000: 1925.
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Editors' Choice

Highlights of the recent literature.
Science 17 March 2000: 1889.
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NetWatch

Best of the Web in science.
Science 17 March 2000: 1883.
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 NEW PRODUCTS

Science 17 March 2000: 2043.

News of the Week

HUMAN GENOME RESEARCH:
SNP Mappers Confront Reality and Find It Daunting

Leslie Roberts
Science 17 March 2000: 1898-1899.
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SCIENTIFIC COMMUNITY:
Oxford Wins a Crown Synchrotron Jewel

Michael Hagmann
Science 17 March 2000: 1899.
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ASTRONOMY:
Distorted Galaxies Point to Dark Matter

Adrian Cho
Science 17 March 2000: 1899-1901.
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SCIENTIFIC MISCONDUCT:
Cancer Researcher Sacked for Alleged Fraud

Michael Hagmann
Science 17 March 2000: 1901-1902.
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CHEMISTRY:
Nanocrystals May Give Boost to Data Storage

Robert F. Service
Science 17 March 2000: 1902-1903.
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GENOME SEQUENCING:
Clinton and Blair Back Rapid Release of Data

Eliot Marshall
Science 17 March 2000: 1903.
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BIOMEDICINE:
Congress Investigates Fetal Tissue Sales

Gretchen Vogel
Science 17 March 2000: 1903-1905.
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GLOBAL CHANGE:
Endorsement for Controversial Satellite

Andrew Lawler
Science 17 March 2000: 1905.
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ScienceScope

Science 17 March 2000: 1901.
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Random Samples

Science 17 March 2000: 1917.
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News Focus

On the Hunt for a Wolf in Sheep's Clothing

Michael Balter
Science 17 March 2000: 1906-1908.
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Writing Scrapie's Coda, Codon by Codon?

Michael Balter
Science 17 March 2000: 1907.
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QUANTUM MECHANICS:
'Spooky Action' Passes a Relativistic Test

Charles Seife
Science 17 March 2000: 1909-1910.
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MATHEMATICS:
Why Double Bubbles Form the Way They Do

Barry Cipra
Science 17 March 2000: 1910-1912.
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MATHEMATICS:
Triple Star Systems May Do Crazy Eights

Dana Mackenzie
Science 17 March 2000: 1910-1912.
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MATHEMATICS:
Random Packing Puts Mathematics in a Box

Charles Seife
Science 17 March 2000: 1910-1912.
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GEOLOGIC MODELING:
Seeing a World in Grains of Sand

Erik Stokstad
Science 17 March 2000: 1912-1915.
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Letters

This Week's Letters

Science 17 March 2000: 1927.
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 Transgenic Crops: A Cautionary Tale

Ronald Nigh, Charles Benbrook, Stephen Brush, Luis Garcia-Barrios, Rafael Ortega-Paczka, Hugo R. Perales;, Shahal Abbo, and Baruch Rubin
Science 17 March 2000: 1927.
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 Electricity Supply

Alan E. Waltar
Science 17 March 2000: 1927.
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 Clinical Research

Ralph Snyderman
Science 17 March 2000: 1927.
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 Hydrogen Storage in Nanotubes

Jianyi Lin
Science 17 March 2000: 1927.
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 Science Under the Nazis

Jacob J. Steinberg; and Manfred D. Laubichler
Science 17 March 2000: 1927.
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 CORRECTIONS AND CLARIFICATIONS

Science 17 March 2000: 1927.
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Books et al.

PHYSICS:
Quantum Mechanics at the End of the 20th Century

Hans Christian von Baeyer
Science 17 March 2000: 1935.
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METHODS OF SCIENCE:
Tools for Thinking

Peter Imhof
Science 17 March 2000: 1935-1936.
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 Browsings

Science 17 March 2000: 1936.
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 Books Received

Science 17 March 2000: 1936.

Policy Forum

INTELLECTUAL PROPERTY RIGHTS:
Reforming the Patent System

John H. Barton
Science 17 March 2000: 1933-1934.
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Perspectives

SIGNAL TRANSDUCTION:
Inositol Phosphates in the Nucleus

Tian H. Chi and Gerald R. Crabtree
Science 17 March 2000: 1937-1939.
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EVOLUTIONARY BIOLOGY:
Limbless Tetrapods and Snakes with Legs

Harry W. Greene and David Cundall
Science 17 March 2000: 1939-1941.
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MOLECULAR SPECTROSCOPY:
H₃⁺--an Ion with Many Talents

Benjamin J. McCall and Takeshi Oka
Science 17 March 2000: 1941-1942.
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HYDROCARBON CHEMISTRY:
Enhanced: Conquering the Carbon-Hydrogen Bond

William D. Jones
Science 17 March 2000: 1942-1943.
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NEUROSCIENCE:
Strengthening Visual Connections

Max Cynader
Science 17 March 2000: 1943-1944.
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Tech.Sight

DRUG DISCOVERY:
Integrating Combinatorial Synthesis and Bioassays

Jörg Rademann and Günther Jung
Science 17 March 2000: 1947-1948.
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 SOFTWARE:
Worldwide Weather Watcher

Kevin Ahern
Science 17 March 2000: 1949.
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 SOFTWARE:
Data Tool

William Seffens
Science 17 March 2000: 1949.
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 SOFTWARE:
A Picture is Worth a Thousand Words

Emile M. Bellott
Science 17 March 2000: 1949.
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 SEISMOLOGY:
Where the Ground Shakes

Linda Rowan
Science 17 March 2000: 1950.
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Reports

Monodisperse FePt Nanoparticles and Ferromagnetic FePt Nanocrystal Superlattices

Shouheng Sun, C. B. Murray, Dieter Weller, Liesl Folks, and Andreas Moser
Science 17 March 2000: 1989-1992.
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Efficient Activation of Aromatic C-H Bonds for Addition to C-C Multiple Bonds

Chengguo Jia, Dongguo Piao, Juzo Oyamada, Wenjun Lu, Tsugio Kitamura, and Yuzo Fujiwara
Science 17 March 2000: 1992-1995.
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Thermal, Catalytic, Regiospecific Functionalization of Alkanes

Huiyuan Chen, Sabine Schlecht, Thomas C. Semple, and John F. Hartwig
Science 17 March 2000: 1995-1997.
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Detection of SO in Io's Exosphere

C. T. Russell and M. G. Kivelson
Science 17 March 2000: 1998-1999.
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Secular Variation of Iron Isotopes in North Atlantic Deep Water

Xiang-Kun Zhu, R. Keith O'Nions, Yueling Guo, and Ben C. Reynolds
Science 17 March 2000: 2000-2002.
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Modulation of Hurricane Activity in the Gulf of Mexico by the Madden-Julian Oscillation

Eric D. Maloney and Dennis L. Hartmann
Science 17 March 2000: 2002-2004.
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Contribution of Increasing CO₂ and Climate to Carbon Storage by Ecosystems in the United States

David Schimel, Jerry Melillo, Hanqin Tian, A. David McGuire, David Kicklighter, Timothy Kittel, Nan Rosenbloom, Steven Running, Peter Thornton, Dennis Ojima, William Parton, Robin Kelly, Martin Sykes, Ron Neilson, and Brian Rizzo
Science 17 March 2000: 2004-2006.
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Cell Surface Engineering by a Modified Staudinger Reaction

Eliana Saxon and Carolyn R. Bertozzi
Science 17 March 2000: 2007-2010.
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A Fossil Snake with Limbs

Eitan Tchernov, Olivier Rieppel, Hussam Zaher, Michael J. Polcyn, and Louis L. Jacobs
Science 17 March 2000: 2010-2012.
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Prostaglandin D₂ as a Mediator of Allergic Asthma

Toshiyuki Matsuoka, Masakazu Hirata, Hiroyuki Tanaka, Yoshimasa Takahashi, Takahiko Murata, Kenji Kabashima, Yukihiko Sugimoto, Takuya Kobayashi, Fumitaka Ushikubi, Yoshiya Aze, Naomi Eguchi, Yoshihiro Urade, Nobuaki Yoshida, Kazushi Kimura, Akira Mizoguchi, Yoshihito Honda, Hiroichi Nagai, and Shuh Narumiya
Science 17 March 2000: 2013-2017.
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Facile Detection of Mitochondrial DNA Mutations in Tumors and Bodily Fluids

Makiko S. Fliss, Henning Usadel, Otávia L. Caballero, Li Wu, Martin R. Buta, Scott M. Eleff, Jin Jen, and David Sidransky
Science 17 March 2000: 2017-2019.
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Reversal of Antipsychotic-Induced Working Memory Deficits by Short-Term Dopamine D1 Receptor Stimulation

Stacy A. Castner, Graham V. Williams, and Patricia S. Goldman-Rakic
Science 17 March 2000: 2020-2022.
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Start Sites of Bidirectional DNA Synthesis at the Human Lamin B2 Origin

Gulnara Abdurashidova, Marta Deganuto, Raffaella Klima, Silvano Riva, Giuseppe Biamonti, Mauro Giacca, and Arturo Falaschi
Science 17 March 2000: 2023-2026.
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A Role for Nuclear Inositol 1,4,5-Trisphosphate Kinase in Transcriptional Control

Audrey R. Odom, Alke Stahlberg, Susan R. Wente, and John D. York
Science 17 March 2000: 2026-2029.
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Rapid Extragranular Plasticity in the Absence of Thalamocortical Plasticity in the Developing Primary Visual Cortex

Joshua T. Trachtenberg, Christopher Trepel, and Michael P. Stryker
Science 17 March 2000: 2029-2032.
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Retinal Stem Cells in the Adult Mammalian Eye

Vincent Tropepe, Brenda L. K. Coles, Bernard J. Chiasson, D. Jonathan Horsford, Andrew J. Elia, Roderick R. McInnes, and Derek van der Kooy
Science 17 March 2000: 2032-2036.
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Motion Integration and Postdiction in Visual Awareness

David M. Eagleman and Terrence J. Sejnowski
Science 17 March 2000: 2036-2038.
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Technical Comments

 Kentucky 31, Far from Home

Kari Saikkonen, Keith Clay, and Jenny Holah
Science 17 March 2000: 1887.
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