COVER Initial stage of Pseudomonas aeruginosa biofilm formation on an explant of human lung tissue. Green shows P. aeruginosa, tagged with a fluorescent protein, on the epithelial surface (red-light microscopic image). The bacteria (2 to 3 µm long) form microcolonies in the intercellular junctions around injured cells. A special section on microbes, immunity, and disease begins on p. 1301 [Image: P. Singh, M. Parsek, T. Moninger, E. P. Greenberg, University of Iowa] .

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