A modification of fluorescence in situ hybridization allowed the detection of the birth of individual actin messenger RNAs (mRNAs), depicted here in a digital image. Within the nucleus (delineated by the blue border), the gene is templating nascent RNAs, represented by the cluster of cubes (voxels). After synthesis, single mRNA molecules spiral away from this transcription site toward the nuclear periphery and move into the cytoplasm. See page 585. [Image: A. Femino]

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