Quick freeze-deep etch electron micrograph of a mouse nerve axon showing a microtubule (25-nanometer diameter, linear tube-like structure) and a cross-bridge (perhaps the motor protein KIF) linking the microtubule and a membranous organelle. Microtubules are a major component of the cytoskeleton and serve as a type of rail along which motor proteins transport organelles inside cells (see page 519). This special issue, introduced by the Editorial on page 459, is devoted to the cell biology of the cytoskeleton. [Image: N. Hirokawa]

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