Reconstruction of a membrane area in a presynaptic nerve cell of a lamprey. When the interaction between the proline-rich region of dynamin and the Src homology 3 domain of another protein was disrupted and the synapse subsequently activated, invaginations formed and clathrin (red)-coated pits (diameter ~0.1 micrometer) accumulated because they were unable to pinch off from the membrane. The reconstruction was based on serial ultrathin sections. See page 259. [Image: O. Shupliakov, H. Gad, P. Löw, P. De Camilli, and L. Brodin]

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