Expression of Fas protein (red) detected by immunohistochemistry on disarrayed thyroid tissue (magnification ~1000) from a patient with Hashimoto's thyroiditis, an autoimmune disorder. Interactions between Fas and its ligand (FasL) control several normal and pathological processes of cell death. Fas expression induced by interleukin-1 on thyroid cells constitutively expressing FasL triggers thyroid cell death and contributes to the pathogenesis of Hashimoto's thyroiditis. See page 960 and the News story on page 926. [Image: Giorgio Stassi]

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