The 1996 Breakthrough of the Year is a set of new weapons against human immunodeficiency virus (HIV), which are shown approaching their viral target. Although past weapons based on the CD4 receptors (gold) failed, an array of new drugs (shown as pills) offer hope to those infected, while basic research on the chemokines and their receptors (in blue) may one day be used to help block HIV infection. See the editorial on page 1987 and the Breakthrough of the Year section, beginning on page 1988. [Illustration: Steve Keller]

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