Human immunodeficiency virus (HIV) docking onto the CD4 receptor of a T lymphocyte with chemokine receptors (blue) at the ready. The face of acquired immunodeficiency syndrome has changed dramatically over the past few years, as a new generation of researchers comes to the fore, a new class of drugs shows promise, and scientists gain new insight into how HIV infects a CD4-bearing cell, its primary target. See the special section (pages 1876-1890), editorial (page 1855), and related reports (pages 1939 and 1955). [Illustration: Terese Winslow]

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