The Genome Project adds a new dimension to questions on gene expression in humans and model systems. A chart on page 415 summarizes progress in the Caenorhabditis elegans Genome Project and indicates some ways information about sequences can be used. News stories, Articles, Perspectives, Policy Forums, and Reports focus on technological developments, clinical applications, and ethical concerns resulting from the burgeoning of genomic information. [C. elegans image: F. Maduro and D. Pilgrim, University of Alberta]

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