This Frontiers in Medicine issue addresses the science and politics of vaccines. The hypodermic syringe, a classic tool of vaccination, may soon be out-of-date. A global effort is under way to produce a ``supervaccine'' that would confer, in a single oral dose, lifetime immunity against many of the major infectious diseases. A special section begins on page 1371 and related Reports on pages 1448 and 1451. [Images: needle, Peter Steiner/The Stock Market; globe, Tom Van Sant/Geosphere Project/The Stock Market. Illustration: E. Carroll]

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