Inspired by Leonardo da Vinci's ``Proportions of the Human Figure According to Vitruvius,'' the cover image symbolizes that the creativity of scientists is at the center of technological advances. Scientists' curiosity about biological processes has often led to discoveries that proved useful for biotechnology. One-half of the figure's appendages are robot-like, showing that technology is an extension of its creator. The figure holds a flask of microorganisms, an antibody, and oligonucleotide primers, representing some of the tools of biotechnology discussed in this issue; the fistful of dollars signifies the entrepreneurial aspect of biotechnology. See pages 1643 to 1681. [Illustration by Julie Cherry]

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