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Site-specific recombination in mammalian cells. Transient expression of a yeast recombinase (FLP) in mammalian cells will either excise specific chromosomal sequences or target integration of extrachromosomal DNA to specific chromosomal sites. In this photomicrograph, excisional recombination permanently activated a chromosomally integrated {beta}-galactosidase construct in the cells that contain a blue histochemical reaction product. See page 1351. [Photomicrograph by Stephen O'Gorman and Geoffrey Wahl]


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Science. ISSN 0036-8075 (print), 1095-9203 (online)