Manifestations of concern with AIDS, the acquired immunodeficiency syndrome, in the United States: children receiving instruction on AIDS prevention in the classroom and the burned-out house of a family with AIDS-infected children. This issue of Science includes articles on the epidemiological, legal, economic, and ethical issues of AIDS. See page 573. [Cover design by Sharon Wolfgang, Washington, DC; classroom scene, Mauro Calingo, Silver Spring, MD; and house, Marc Beaudin, News-Press, Fort Myers, FL]

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