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Vol. 323 no. 5911 pp. 220-221
DOI: 10.1126/science.1166261
  • Perspective

Pluripotent Chromatin State

  1. Bradley E. Bernstein1,2,4
  1. 1Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA.
  2. 2Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  3. 3Stephen E. and Catherine Pappas Center for Neuro-Oncology, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
  4. 4Department of Pathology, Harvard Medical School, Boston, MA 02115, USA. E-mail: bernstein.bradley{at}


Chromatin in pluripotent embryonic stem cells may act as a buffer to transcriptional noise.