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In the 24 July 2009 issue, Science highlights how network analysis is allowing us to understand how the world works from new vantage points. Perspective articles examine the foundations of network analysis and its applications across disciplinary fields from economics to ecology; News stories look at the use of network tools to study social phenomena; and a Review article explains how molecular biologists are using networks to analyze basic cellular circuitry. Science Careers highlights careers in network science and the 28 July issue of Science Signaling delves into the dynamics of cell signaling networks.
In Science
INTRODUCTION
- Connections
- Barbara R. Jasny, Laura M. Zahn, Eliot Marshall
NEWS
- Ourselves and Our Interactions: The Ultimate Physics Problem? (Science Podcast)
- Adrian Cho
- Econophysics: Still Controversial After All These Years.
- Adrian Cho
- Counterterrorism's New Tool: 'Metanetwork' Analysis
- John Bohannon
- Investigating Networks: The Dark Side
- John Bohannon
PERSPECTIVES
- Scale-Free Networks: A Decade and Beyond
- Albert-L. Barabási
- Revisiting the Foundations
of Network Analysis
- Carter T. Butts
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PERSPECTIVES
- Disentangling the Web of Life
- Jordi Bascompte
- A General Framework for Analyzing Sustainability of Social-Ecological Systems
- Elinor Ostrom
- Economic Networks: The New Challenges
- Frank Schweitzer, Giorgio Fagiolo, Didier Sornette, Fernando Vega-Redondo, Alessandro Vespignani, Douglas R. White
- Predicting the Behavior
of Techno-Social Systems
- Alessandro Vespignani
REVIEW
- Transcriptional Regulatory Circuits: Predicting Numbers from Alphabets
- Harold D. Kim, Tal Shay, Erin K. O'Shea, Aviv Regev
SEE ALSO
- Policy Forum: Can We Reinvent the Internet?
- Viktor Mayer-Schönberger
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In Science Signaling
EDITORIAL GUIDE
- Focus Issue: Unraveling Signaling Complexity
-
Nancy R. Gough and John F. Foley
Dynamics adds to the complexity of signaling networks.
RESEARCH ARTICLES
- Cell Type–Specific Importance of Ras–c-Raf Complex Association Rate Constants for MAPK Signaling
-
Christina Kiel and Luis Serrano
Ras–c-Raf association rates affect downstream signaling in the absence of negative feedback but not its presence.
- Comparative Analysis Reveals Conserved Protein Phosphorylation Networks Implicated in Multiple Diseases
-
Chris Soon Heng Tan, Bernd Bodenmiller, Adrian Pasculescu, Marko Jovanovic, Michael O. Hengartner, Claus Jørgensen, Gary D. Bader, Ruedi Aebersold, Tony Pawson, and Rune Linding
Comparing the human phosphoproteome to that of flies, worms, and yeast reveals insight into evolution and disease.
- Integrating Proteomic, Transcriptional, and Interactome Data Reveals Hidden Components of Signaling and Regulatory Networks
-
Shao-shan Carol Huang and Ernest Fraenkel
Analysis of multiple "omic" data sets with a prize-collecting Steiner tree algorithm reveals components of signaling networks that are not obvious by analyzing the data individually.
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PERSPECTIVES
- Understanding Modularity in Molecular Networks Requires Dynamics
-
Roger P. Alexander, Philip M. Kim, Thierry Emonet, and Mark B. Gerstein
Understanding Modularity in Molecular Networks Requires Dynamics
- Proteomic Revelation: SUMO Changes Partners When the Heat Is On
-
Karin Flick and Peter Kaiser
A system-level view of SUMOylation dynamics shows the importance of SUMOylation to the heat shock response.
- The Complexity of Cell Signaling and the Need for a New Mechanics
-
William S. Hlavacek and James R. Faeder
Studies that make sense of protein networks provide approaches to cope with complex signaling pathways.
- Dynamic Advances in NF-κB Signaling Analysis
-
Taeko Kobayashi and Ryoichiro Kageyama
Cytokine stimulation of cells at different time intervals produces distinct patterns of NF-κB–dependent gene transcription.
PODCAST
- Science Signaling Podcast: 28 July 2009
-
Michael B. Yaffe and Annalisa M. VanHook
Science Signaling's Chief Scientific Editor discusses complexity in signaling networks.
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In Science Careers
