Smarter imaging: Gaining more from your microscopy experiments

“What is the mechanism?” This is a fundamental question that drives many biological research programs. Imaging experiments have been trending toward higher-content approaches in order to delve deeper into the mechanism and increase data fidelity. In this digital supplement, we highlight several recent studies from researchers that not only use high-throughput methods but combine them with novel engineering techniques, whether at the specimen or platform level, to gain more from their imaging experiments.

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