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Sequencing collection

The fundamental principle on which sequencing technology is based has essentially not changed since its development by Fred Sanger in 1977. Although a number of significant improvements have been made, the methodology still has a number of inherent technical and physical limitations, such as the limited throughput of samples and the requirement for cloning and amplification of the DNA prior to sequencing. This circumstance has prompted the development of a number of new technologies through which researchers have looked at the problem afresh and proposed interesting solutions, or presented novel twists on the original Sanger technique. This booklet showcases articles using such sequencing technologies.

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