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E-Letter responses to:

editorial:
Floyd E. Bloom
Just a Minute, Please
Science 1999; 285: 197 [Summary]
*E-Letters: Submit a response to this article

Published E-Letter responses:

[Read E-Letter] Peer Review Versus Open Submission
Dr. Paul Thind   (18 April 2001)
[Read E-Letter] A vote of confidence for E-biomed
Jane Gitschier   (31 July 1999)
[Read E-Letter] Advancing Science By Self-Archiving Refereed Research
Stevan Harnad   (31 July 1999)
[Read E-Letter] E-biomed craziness
Charles H. Halsted   (26 July 1999)
[Read E-Letter] Readers Should Note..
Anne Thomas   (26 July 1999)
[Read E-Letter] E-biomed raises bigger issues
Peter McDonald   (22 July 1999)
[Read E-Letter] Money and Power
David B. Bylund   (22 July 1999)
[Read E-Letter] Users are well served by the present system
Vincent Marchesi   (20 July 1999)
[Read E-Letter] E-biomed - is it information overload.
Richard W. Burry   (20 July 1999)
[Read E-Letter] A Great Advance
Nicholas R. Cozzarelli   (19 July 1999)
[Read E-Letter] Publishing: Fast buck versus improving health care
J. Buchanan   (14 July 1999)
[Read E-Letter] Is E-biomed a sound idea?
Tapan Das   (9 July 1999)

Peer Review Versus Open Submission 18 April 2001
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Dr. Paul Thind,
Electronic Publishing
ARKAT Foundation

Respond to this E-Letter:
Re: Peer Review Versus Open Submission

We are publishing a free online journal of organic chemistry http://www.arkat.org and have debated this issue in connection with a chemistry preprint server. Our conclusion is that you cannot replace peer-reviewing with no peer-reviewing. The two have to run side by side with the later serving perhaps as the "warehouse of information." Such a warehouse resource can allow the readers to judge what is of value and for industry to see what could be useful. More important, it can serve as the "record date," for reporting of inventions. From this "warehouse," completed and sound works can be moved to a peer- reviewed publications when and if authors wish it.

A vote of confidence for E-biomed 31 July 1999
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Jane Gitschier
University of California, San Francisco and Howard Hughes Medical Institute

Respond to this E-Letter:
Re: A vote of confidence for E-biomed

I applaud Harold Varmus and his colleagues for developing the E- biomed initiative. E-biomed is not only long overdue - it is inevitable. I’m sure the scientific community soon will look back on this period of debate and wonder what all the fuss was about. E-biomed will enhance scientific dialog and democratize the scientific process. The nuts and bolts of peer-review, fees, alliances with professional societies, copyrights, etc. are details to be worked out, to be sure. But the strength of immediate, free, and world-wide electronic access to scientific discoveries should be the overriding guiding principle in our discussions. As to whether the NIH, possibly in collaboration with international partners, should be the repository for E-biomed, one may look to the success and efficiency of GenBank.

Advancing Science By Self-Archiving Refereed Research 31 July 1999
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Stevan Harnad
Southampton University, UK

Respond to this E-Letter:
Re: Advancing Science By Self-Archiving Refereed Research

The Editor of SCIENCE, Dr. Floyd Bloom has written an editorial about NIH's E-biomed initiative (http://www.nih.gov/welcome/director/ebiomed/ebiomed.htm)

Floyd E. Bloom [Editorial] "Just a Minute, Please" SCIENCE 285 (5425) p. 197, 9 Jul 1999 (http://www.sciencemag.org/cgi/content/summary/285/5425/197 This is a reply to his editorial. To summarize, Dr. Bloom is writing ex officio as the Editor of Science, published by the American Association for the Advancement of Science. Science is a hybrid journal. It contains articles by salaried staff writers and commissioned articles written for a fee. It is important to note that these articles are in no way at issue here.

But Science also contains refereed research reports, submitted by their authors for free, with the sole objective of making the research findings available as broadly as possible once they have met Science's rigorous standards of peer review. It is these refereed articles only that are under discussion here, and the issue is a simple one: Should NIH/E-biomed provide a free public Archive, modelled on the NSF-supported Los Alamos Eprint Archive in Physics (LANL) (http://xxx.lanl.gov/), in which the authors of these refereed research reports can self-archive them online publicly, free for everyone, everywhere, forever?

Dr. Bloom is arguing that they should not be, and we will shortly examine his reasons. But we can be confident that Dr. Bloom will revise his views when more fully informed of the objectives of E-biomed and the scientific potential of free public archiving of refereed research on the World Wide Web, for Dr. Bloom represents the American Association for the Advancement (not the secondary sale or suppression!) of Science.

At the moment, Dr. Bloom's reservations are motivated by two factors: Concern about the quality of the scientific research literature (and this concern is commendable, his journal being the representative of research standards of the highest quality) and concern about the revenue stream of his journal, which is the financial resource that is currently supporting those high standards of quality. It is here that I am afraid that Dr. Bloom is being somewhat short-sighted and perhaps even a little partisan too, unconsciously placing the interests of the maintenance of that revenue stream above the interests of the science that AAAS is dedicated to advancing.

It is undeniable that in the present PostGutenberg Era a conflict of interest has arisen between researchers and the current means of production of their published refereed research reports. There is a way to resolve this conflict, however, although it at first appears counterintuitive; and as the resolution is clearly to the benefit of science, and at the same time provides the revenue stream to sustain the essential service provided by the publishers of science -- quality control and certification in the form of peer review and editing -- there is every reason to believe that AAAS will find it fully compatible with its mission.

The resolution is a two-stage one.

First, it is necessary to identify and acknowledge the conflict of interest:

For scientific researchers, the reports of their (usually publicly funded) research findings are GIVE-AWAYS: They seek neither royalties nor fees; they seek only the eyes and minds of their fellow-researchers worldwide, present and future, so as to maximize the impact of their findings on the future course of research (and thereby also on the course of their careers and their livelihoods).

Researchers are accordingly interested in having their findings first quality-controlled and certified (QC/C) through peer review, and then made freely accessible to everyone. In the Gutenberg Era, the only way they could come anywhere near that goal was to treat their work exactly the same way trade authors (who wrote for fees or royalty) treated theirs, namely, to assign copyright to a publisher, who would then charge for access to the work in order to cover the substantial expenses of paper publication and distribution and to make a fair profit, where possible, for both himself and his author (in the form of royalties or fees).

But the scientists reporting their research findings in refereed journals were never interested in fees or royalties, for those would represent access barriers, restricting their findings to only those individuals and institutions that could afford to pay for them [via subscription, site license, or pay-per-view (S/L/P)]. Nevertheless, scientists had to live with these S/L/P barriers, for all the world as if they were trade authors seeking royalties or fees for their work, because in the Gutenberg Era there simply was no alternative way to reach even that privileged subset of the potential readership of their article (not a large populace even in the best of times).

In the PostGutenberg era of global digital networks, however, there is at last an alternative, and not only researchers, but research itself, and hence all of society, would be the losers if we failed to take full advantage of it. For now we no longer have to rely on the expensive, inefficient and access-limiting technology of print on paper to disseminate refereed research findings. They can be SELF-ARCHIVED by their authors in public online archives like E-biomed (and its spectacularly successful model, LANL) and thereby accessible to one and all without any financial firewalls.

http://www.arl.org/scomm/subversive/toc.html http://www.cogsci.soton.ac.uk/~harnad/nature.html

Free public self-archiving, however, is only the first of the two stages of resolving the conflict of interest between research and its current means of publication. As long as there continues to be a demand for the paper version, it (and its proprietary online counterpart) can continue to be sold via S/L/P, which can continue to fund (among other things) QC/C (peer review). But meanwhile the worldwide research community will also have the self-archived online version on its desktops for free. And there is every reason to believe that they will grow increasingly reliant on it.

http://xxx.lanl.gov/cgi-bin/show_weekly_graph

Eventually, this is likely to shrink S/L/P revenues, and here it may look as if we are approaching a catastrophe point, for part of that revenue is paying for the maintenance of the quality standards of that literature. But a very simple solution is available, once we recognize that the S/L/P revenues are largely being paid for by their researchers' institutions. Let us call this "reader-institution end" funding. All that is needed to continue covering QC/C costs is to switch from reader-institution end funding to author-institution end funding, covered fully by the S/L/P savings. The big difference is that reader-institution-end S/L/P is access-blocking, holding the literature hostage to access tolls, whereas author-institution end funding makes access completely free.

This is the second stage of the resolution of the conflict of interest, and it has the further advantage (although this is more controversial, because no one has the exact figures yet) that it will save institutions a great deal of money. For the cost of QC/C alone -- once publishers have scaled down to providing this essential service alone, leaving the access providing and preservation entirely to public online archives like LANL and E-biomed -- is likely to be much lower than current S/L/P expenditure. Indeed it is likely to be less than 1/3 of it, by current estimates. See the American Scientist Discussion Forum threads on this:

http://amsci-forum.amsci.org/archives/september-forum.html

Odlyzko, A.M. (1998) The economics of electronic journals. In:

Ekman R. and Quandt, R. (Eds) Technology and Scholarly

Communication Univ. Calif. Press, 1998.

http://www.research.att.com/~amo/doc/economics.journals.txt

This means that researchers benefit (access to their findings is expanded, potentially infinitely), their institutions benefit (both from S/L/P savings and from their researchers' enhanced impact), and research itself benefits (in both productivity and pace). Refereed journal publishers will unfortunately need to downsize, but in exchange they will have a stable, permanent niche that is compatible with the new medium rather than at odds with it.

Now I proceed to reply to Dr. Bloom's editorial on a quote/comment basis:

> Proponents [of the E-biomed Archive] acknowledge that cooperating > journals could lose subscription income and suggest that journals > recover their costs through submission and acceptance fees charged to > authors. E-biomed may be free to users, but it will not be free to > taxpayers or authors submitting through peer review.

We can now understand that this passage is based on a misunderstanding. Tax payers are already sustaining our educational and research institutions, including their S/L/P budgets, which will be REDUCED rather than increased by the switch to up-front payment in the online-only era.

And the costs of providing public research archive facilities such as LANL and E-biomed will be minuscule compared to the size of the literature and the benefits conferred; moreover, most of the infrastructure is in place already, in this increasingly networked world, and pooling resources with the rest of the disciplines (after Physics and the Biomedical Sciences) will make the marginal costs even more minimal.

So there is nothing whatsoever in this passage to deter us from resolving this conflict of interest in the way just described.

> [E-biomed has] much support from quarters long known to advocate a more > open scientific literature that would banish the alleged cabals of > editors, biased reviewers, and expensive commercial presses with > generally irrelevant content.

There are as always extremists around who want to banish QC/C, but leveller heads are bent on preserving it, and indeed the entire scenario just described is predicated on just that.

http://helix.nature.com/webmatters/invisible/invisible.html

So this objection too is invalid.

> Lurking behind the public discussions are some potentially troubling > elements:

> What if the major journals choose not to cooperate out of concern that > their ability to survive and maintain quality control and timeliness > are threatened by the diversion of authors and competent reviewers into > the NIH system?

There was a little confusion in the initial draft of the E-biomed proposal. The eventual goal is cooperation with the refereed journals, in the form of official "overlays" on the archive, authenticated by them. But in the first stage, author self-archiving of their refereed drafts will suffice to free the literature.

http://www.nih.gov/welcome/director/ebiomed/com0509.htm#harn45

Nor is there any "diversion of authors and competent reviewers into the NIH system." There is no "NIH system," merely a public archive in which authors can deposit their papers (both refereed reprints and, if they wish, unrefereed preprints).

There is only one respect in which the major journals need to "cooperate," and one certainly hopes they will do so, otherwise this will escalate the conflict of interest instead of resolving it to the benefit of science: Publishers must not attempt to use copyright restrictions as a weapon to continue to hold the literature hostage to access tolls by forbidding public self-archiving.

This is THE central issue, and at the heart of all of this. SCIENCE itself has published a collective call for the retention of such author rights

http://www.sciencemag.org/cgi/content/full/281/5382/1459

along with a dissenting editorial by Dr. Bloom.

http://www.sciencemag.org/cgi/content/summary/281/5382/1451

Some prior comments on that exchange in SCIENCE are appended at the end of this reply. Let it only be noted here that progressive publishers are already resolving this conflict in a fair and rational way, in the interests of the scientific community they serve, rather than their own S/L/P revenue streams. A model in this regard (and they will be duly recognized by historians for this) is the American Physical Society (APS), publisher of the journals with the highest QC/C standards and impact factors in Physics. Dr. Bloom's homonomyous APS counterpart, Dr. Blume, is one of the cosignators of the above copyright reform proposal in SCIENCE. For APS copyright policy, see:

http://www.cogsci.soton.ac.uk/~harnad/Hypermail/Author.Eprint.Archives/

> Will societies whose members' future careers rely on NIH funding be > willing to resist the cooptation of their journals' editorial and peer > review systems?

Nothing is being co-opted. The NSF-funded LANL Physics Archive stands as a model for the kind of cooperative solution that will prevail. Journals, editorial boards and peer review will continue to exist, independent and intact. The only issue is whether they should be allowed to continue to try to hold this give-away literature hostage to S/L/P access tolls, against the interests of research and researchers.

> What will the real costs be to authors, peer-reviewed journals, and > scientific societies?

Yes, what will they be indeed, once the obsolete Gutenberg "add-ons" are phased out and only the essential QC/C costs remain?

> Does a monopolistic archive under government control by the major > research funder enhance scientific progress better than the existing > journal hierarchy, which provides multiple alternatives to authors and > readers?

Multiple journals -- indeed the entire hierarchy that currently exists -- will continue to exist for authors and readers. Nor will it be government controlled. (As always, quality will be controlled by peer reviewers, who, like the authors, do their work for free! QC/C costs are for IMPLEMENTING peer review, not for actually performing it.)

NIH will fund E-biomed, just as NSF funds LANL. The cost will be minuscule, and still smaller as more disciplines join in the self-archiving initiative. And once S/L/P expenditures shrink, savings will prevail, including savings on government-supported institutional serial budgets.

Pluralism will be, if anything, enhanced by a firewall-free global research literature. The objective is to free the literature from market restrictions that are no longer justified or necessary, not to take over a market!

(The word "monopoly," so clearly out of place here, will recur later in this reply in the context of certain collaborative firewall practises on the part S/L/P providers...)

> What about research in disciplines outside what the National Library of > Medicine considers biomedical?

There are plans for vetting the unrefereed clinical preprint sector to safeguard public health, but no planned restrictions of any sort on the refereed sector, any more than there are any such restrictions on the LANL Archive. (One wonders what Dr. Bloom has in mind here?)

> What about research not sponsored by NIH or even U.S. federal funds?

The answer to this question is so obvious, one can only wonder why it was raised: What about research not sponsored by NSF in LANL? What about LANL's 14 mirror sites around the world? Why on earth would an archive dedicated to freeing access to the refereed research literature for the world scientific community through self-archiving have any interest in blocking access to any of it? (The only interests vested in blocking access to this corpus at the moment are certainly not governmental ones...)

> Without answers to these and other questions, it is hard to determine > the feasibility of the proposal.

(The answers are in each case so trivially obvious that one can only wonder what the real source of the reservations about feasibility might be!)

> Science and other journals are eager to identify the advantages of the > E-biomed proposal and are actively looking for changes that could > benefit scientific publishing.

The advantage of the E-biomed proposal is that it will free the refereed journal literature, to the benefit of science, scientists, and humankind. The only change required at the moment is a copyright policy that clearly recognizes the no-royalty/no-fee author's right to self-archive along the lines of the APS policy.

http://www.cogsci.soton.ac.uk/~harnad/Hypermail/Author.Eprint.Archives/0006.html

> For example, the E-biomed server would provide a venue for online > publication of negative results and thus allow others to avoid > experimental repetition.

Among the much more profound benefits of public online self-archiving of refereed reprints and unrefereed preprints there is also the more modest one of being able to self-archive negative results, both those that have been accepted by refereed journals, and those that were not.

> On the other hand, if NIH really wants to improve access to the > literature, they could digitize the peer-reviewed literature published > before 1995.

The retroactive peer-reviewed literature is most certainly welcome in the free public archives, and will most certainly be deposited there, both by individual authors and by digitization initiatives (neither LANL nor E-biomed is a digitization initiative: they are public self-archiving initiatives).

But exactly what is the benefit to science of restricting availability to the pre-1995 literature?

> In addition, all would benefit if NIH developed software for online > journal submittals and provided access to a common search engine that > could survey all peer-reviewed sciences across all journal lines.

The first benefit, though undeniable, is likewise not E-biomed's mandate. (Why should NIH develop submission software tools?) On the other hand, the practise of self-archiving will certainly help accelerate the development of such tools, and it will hasten and expand authors' using them. Moreover, once the second stage is reached, official journal overlays on E-biomed will allow automatic online submission to the journals via the archive, as is already being implemented on LANL in collaboration with the APS.

As to providing the capacity to "survey all peer-reviewed sciences across all journal lines," this will be trivially provided by E-biomed and any number of generic search engines as soon as the self-archiving initiative is well under way, and E-biomed is well stocked with papers searchably tagged as "U" (unrefereed preprint) or "R" (refereed reprint, together with journal name "Jx").

But the principal advantage of this free public archive will be that it will indeed be "across all journal lines" without any of the financial firewalls that criss-cross the proprietary online corpus as it now stands -- a state of affairs that some would like to see turned into a "click-through" monopoly governed by interpublisher S/P/L fee agreements!

http://www.cogsci.soton.ac.uk/~harnad/citation.html

> It may be instructive to recall an earlier congressional reaction, as > Albert Henderson, editor of Publishing Research Quarterly did in his > response to E-biomed on 6 May. In the Sputnik aftermath, an > E-biomed-like proposal was made that Congress accelerate U.S. > scientific research by establishing a unified information system > similar to what had been created in the Soviet Union. The Senate's > advisory panel responded: "The case for a Government-operated, highly > centralized type of center can be no better defended for scientific > information services than it could be for automobile agencies, > delicatessens, or barber shops." Surely other creative solutions can be > found to what NIH considers problems. Are they prepared to listen, or > is this a done deal?

Both Dr. Henderson and Dr. Bloom might benefit from being reminded (if they will only listen!) that unlike the producers of cars, bagels and haircuts, the producers of refereed journal articles wish to give them away for free. And there is no earthly reason why any government should not wish to help them do so, to the eternal benefit of science and society worldwide.

This would have been as welcome in the Sputnik era as it is today, but we had not yet reached the PostGutenberg Galaxy at that time.

The only costs that remain to be paid are those for the SERVICE of implementing QC/C, costs that it will make incomparably more sense for the author-institution to pay up-front, out of S/L/P savings, thereby freeing the literature for one and all, along with a considerable institutional saving, rather than at the access-denying reader-institution end, for the reasons described above.

E-biomed craziness 26 July 1999
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Charles H. Halsted
University of California Davis School of Medicine

Respond to this E-Letter:
Re: E-biomed craziness

Both as a journal editor and scientist competing in the arena of biological research, I view E-biomed as a harebrained idea with potentially disasterous consequences. The idea would spell the death knell for basic and clinical bioscience journals which currently, through a system of competition, are a major mechanism for assuring excellence of the scientific enterprise. As an editor dedicated to improving the impact of my journal, the American Journal of Clinical Nutrition, I have learned the importance of stringent and incisive peer review which, I believe, in the long run assures ever-increasing demand for scientific excellence from our authors. The Ee-biomed system would do away with all of this, since a) there would be no competition among journals and b) there would be no editors striving for excellence in their fields through demanding high standards of submissions. Instead, I fear, the uniform E-biomed journal would be run by government or NIH political appointees or otherwise subject to in-house NIH political pressures. Meanwhile,competitive journals and their ponsoring societies would wither away, since there would be no incentive for subscriptions and there would be no incentive for authors to pay page charges since E-biomed would be free. The independent societies would die without journal income.

Along with other scientists, I would learn very quickly that the currency of my work would be devalued to a common denominator determined by the appointees who run the common E-biomed outlet. The idea of two separate pathways -- one for publishing just data in a hurry, and the other for publishing peer reviewed data -- would quickly become blurred, since every author thinks his/her data must be published as soon as possible. A single rapid review and publication process would be great for salami scientists who love to publish minutia, e.g. the latest permutation in one's favorite gene, but what about thoughtful scientists who have original and comprehensive new concepts that should be evaluated by stringent peer review before they are thrown open to full view by the scientific community? Overall, the risk is mediocrity -- just having a vehicle for getting the facts out as quickly as possible is a far cry from developing and proving cohesive and defensible new hypotheses that truly advance understandings of biology, health, and disease. In this new world of rush to publication of minutiae, there will be no way to distinguish important from mediocre science, and all scientific discovery will be devalued.

Lastly, as an ethical physician I greatly fear the rush to publication of incomplete clinical data. In the nutrition field, many are especially vulnerable to pressures of the vast supplement industry to promote incomplete data on the apparant value of this or that product, without clear indication of its safety and efficacy. The rush to publish new observations prior to well thought out, and, most importantly, carefully peer reviewed clincal trials, will be a much greater temptation in the world of E-biomed. Patients and the public will suffer along with the scientific enterprise in its decline to mediocrity.

Readers Should Note.. 26 July 1999
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Anne Thomas,
Associate Director for Communications
National Institutes of Health

Respond to this E-Letter:
Re: Readers Should Note..

Readers of Floyd Bloom's editorial in Science, July 9, 1999, should be aware that his comment that "Editorial assessments in the New England Journal of Medicine, Wall Street Journal, and New York Times reflect very serious concerns about the (E-biomed) proposal," is misleading. The New York Times didn't publish an editorial about E-biomed; they published a news story by Robert Pear on June 8, 1999. Bloom's editorial may leave the impression that these articles were mostly negative, but we read the Wall Street Journal commentary ("The Gutenberg Internet," June 11, 1999) and the New York Times piece as mostly positive about the E-biomed proposal. Also, Bloom did not mention other editorials on the subject: Lancet published an editorial, "NIH e-biomed proposal: a welcome jolt", June 12, 1999, and the Los Angeles Times published an editorial, "New Forum for Medical Research", July 12, 1999 (after the Bloom editorial appeared in Science). Both of these commentaries, in our view, took very positive positions on the E-biomed proposal. We hope that interested people will read all of these articles and draw their own conclusions.

Bloom's editorial also raises a series of questions and implies that none of them have been answered. Many of them in fact have been answered, either in the original E-biomed proposal of May 5, in the addendum of June 20, or in public discussion. For example, NIH has said that the research disciplines included in E-biomed could (and would and should) go beyond what the National Library of Medicine considers biomedical. We have also made clear that research not sponsored by NIH or even with U.S. federal funds would certainly be welcomed by the E-biomed system.

At the end of his editorial Bloom asks: "Are they prepared to listen, or is this a done deal?" We have listened and we are still listening. We've invited comments about the proposal since May 5 and have posted more than 200 responses on our web site. Dr. Varmus has held public discussions with a number of interested groups, including a large group of science journalists. We continue to read all the comments posted on our message board and on this message board. We think something like the E-biomed proposal is going to happen. What the final shape will be, we don't know. We are still listening. And we are glad we started up a lively discourse.

E-biomed raises bigger issues 22 July 1999
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Peter McDonald,
Geneva Library
Cornell University

Respond to this E-Letter:
Re: E-biomed raises bigger issues

In his editorial of 7/9 "Just a Minute, Please", Floyd Bloom raises many important issues and their implications regarding NIH's proposed pre-print server for biomedical literature. There is, however, one area regarding a biomed preprint archive which Mr. Bloom fails to mention.

When Dr. Varmus, director of NIH, proposed the E-biomed server, two objectives were discussed. First (and Mr. Bloom addresses this) E-biomed was seen as a response to the needs of scientists to have timely access to the literature in a manner not unlike the physics eprint archive at LANL. But equally important, Varmus clearly saw and articulated that there is a crisis in scholarly publishing (most notably in the sciences), where academic institutions pay handsome salaries and provide infrastructure to faculty to conduct important research, only to have the fruits of that research and the copyright to the corresponding literature delivered to commercial publishers, often with page charges attached, who in turn then sell that information right back to academic libraries at inflation rates in excess of 10%-15% per year. With academic library budgets rising at best at a rate of 3%-5% a year, it doesn't take a rocket scientist to figure out the maths. It is, bluntly put, a ludicrous system, and for academic libraries especially, entirely unsustainable and inequitable. Indeed, previous editorials in SCIENCE have spoken eloquently of this very crisis.

Whether NIH's vaulted plans for E-biomed ever come to fruition (not likely now with BioOne being proposed: See "Chronicle of Higher Education", vol XLV, No. 43, July 2nd, 1999 ppA22.) what the proposal has done is spark an important debate about the need for alternatives to the current methods of scholarly publishing in the sciences which are currently so hopelessly out of whack and untenable. To this end, the NIH proposal has done a world of good in raising the issue front and center in the mainstream science press. Bloom's comments are well taken, but he missed half the argument.

Money and Power 22 July 1999
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David B. Bylund
University of Nebraska Medical Center

Respond to this E-Letter:
Re: Money and Power

Being only slightly cynical, the disagreements over the E-biomed proposal (as is true for many disagreements) can be reduced to two basic issues: money (in this case, who pays the costs) and power (who decides what is published and where it is published). The original E-biomed proposal has been modified somewhat, so now there is less disagreement over power issues. Money, however, is still an issue.

Free and open access to all biomedical (or by extension, all scientific) literature is a worthy goal. The dilemma, of course, is that publishing (print or electronic) is not without cost. But who pays? Under the current system, most of the cost is borne by the user of the information (most commonly through a library). By contrast, under the proposed system the author would bear most of the cost (most likely through grant or institutional funds). This is a fundamental change and one that is not necessarily dependent on electronic communication. As is true with any complex system, a major perturbation to the publishing system such as that envision by this proposal may well have significant adverse (although unintended) consequences. Thus, as Floyd Bloom's editorial cautions, there is more of a need for careful deliberation than for speed. Indeed, this is not something that needs to be done quickly, certainly not with in the next few months.

Given the historical reliance on investigator initiated grants at NIH, it would seem that any E-biomed system should preferably develop from the ground up (rather that being imposed from the top down), the way the Los Alamos National Laboratory ePrint Server developed. It is my hope that whatever system evolves will take maximum advantage of the unique potentials of electronic communication -- not just an electronic copy or extension of the printed page. It would appear to me that a system mandated or managed centrally by NIH would be less likely to be innovativeand responsive to the rapidly changing capabilities of electronic communication.

I am the Editor of Pharmacological Reviews, published online by the American Society for Pharmacology and Experimental Therapeutics in cooperation with HighWire Press.

Users are well served by the present system 20 July 1999
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Vincent Marchesi
Yale University

Respond to this E-Letter:
Re: Users are well served by the present system

The concerns you raise about E-biomed and its effects on scientific publications are valid and need answers before any centrally run, electronic publications service is actually launched. But it is also worth pointing out that, from the point of view of the users, the system that now exists for the distribution of research findings is remarkably efficient. Certain high impact journals capture the most dramatic (and usually interesting) new data in fast-moving fields, so we consult them unfailingly. We search out discipline-based journals of reputation because their manuscripts are validated by zealous reviewers, who examine everything with the microscope of criticism. If we look closely, we realize that there are varying levels of impact in different fields and many discipline-based journals of lesser prestige that are regularly tracked by knowledgeable investigators. In other words there is a hierarchy of expectations and delivery that we have come to rely on.

One might say that print journals and their readers have developed symbiotic feedback loops that have value and advance the progress of science. The electronic versions of these same journals add significantly to their impact, precisely because they enhance products we know and trust. They help scientists find and use new information efficiently. Scientific productivity is enhanced, and the public gets more for its money.

If the goal is to eliminate print journals because they cost too much, one hopes that an effort will be made to retain the good parts of a system that really works pretty well.

E-biomed - is it information overload. 20 July 1999
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Richard W. Burry
Ohio State University

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Re: E-biomed - is it information overload.

I am concerned because the implementation of the proposed Preprint server will have negative impact on the publication of scholarly and scientific work. We scientists are currently very excited about the potential for communication on the Internet, but I feel we have forgotten one important function that journals serve. If there was a site which allowed anyone to list data or manuscripts that had not been reviewed, I do not think I could bring myself to look at it. The major reason is there would be substandard or poorly done work listed, and I do not have hours to spend looking through this material. It is currently difficult to find time for each issue of Current Contents, let alone trying to find interesting unreviewed material. A better use of the internet is to allow journals to use their review process to screen manuscripts and then post the articles on web sites, just as many society based journals are now doing with HighWire Press. We do not need access to more unreviewed information but better access to high quality information. The E-biomed preprint site will not help scientists find new information, rather it will be an information overload for scientists. Rather than create E-biomed, why not find better ways for the Society based journals to review manuscripts faster, and then to get the manuscripts on subscriber based web sites faster.

I am Associate Editor for the Journal of Histochemistry and Cytochemistry, published online in cooperation with HighWire Press.

A Great Advance 19 July 1999
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Nicholas R. Cozzarelli
University of California at Berkeley

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Re: A Great Advance

Free access to the scientific literature would be a phenomenal advance in scientific publishing--the greatest of our lifetime. It will speed up scientific discovery, reduce duplications, help democratize inquiry, increase the accuracy of attributions, and promote instruction, particuliarly at small colleges and in foreign countries. The realization of its potential should impel us to find a way to make E-biomed work. Whatever risks there are, and I see them as minimal, they are dwarfed by the enormous benefits of E-biomed. Floyd Bloom is opposed to a "monopolistic archive under government control." So is Varmus. A decentralized form of E-biomed that maintains journal identity and integrity is clearly possible. That is what a number of scientists are working to help achieve. The oft-repeated argument that E-biomed gives too much control to NIH has little weight. A decentralized E-biomed with an independent scientific advisory board will increase NIH power insignificantly. We trust NIH with the dministration of almost 14 billion dollars a year in research funds. E-biomed pales in comparison. NIH already runs journals. I can not conceive of a study section saying that someone should not get a grant because they do not publish in NIH journals. If journals continue to provide essential service to science, as they do now, they will thrive. E-biomed will just change the way journals recover costs. There is nothing particuliarly compelling about the present system, which relies heavily on high subscription rates for libraries and other institutions. It just has evolved that way. I wish to acknowledge that I am the editor of the Proceedings of the National Academy of Sciences. My experiences as editor have shaped my views, but the comments above reflect my personal opinion.
Publishing: Fast buck versus improving health care 14 July 1999
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J. Buchanan

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Re: Publishing: Fast buck versus improving health care

The Editorial comment "Taking More Interest in Conflict" in the July issue of Nature Medicine is the most graphic illustration of the problems confronted by peer reviewers, the journals and the readers. "The twin aims of improving health and making money are not incompatible, but the wise biomedical researcher who has a commercial interest in his or her work appreciates that in the long term, the best way to make money from biomedical research is to generate impeccable science from which solid, informative and wise conclusions are drawn, in the expectation that only this caliber of knowledge will yield the safest and most effective products for diagnosing, prognosing, treating and curing disease--market forces will then take care of the rest."

I do not think that many authors in the journals follow this thought process or the journals would not be adopting the policy to disclose any financial conflicts of interests. Some journals even allow the author to seek out those peer reviewers who would give them a more favorable review or eliminate those who would not. This says much about the peer reviewers, the authors. and the editors of the journals themselves. If you continue to replow old ground, no new theory is advanced in the journals or in the information process.

The stated goals of the E-biomed proposal are to provide free access to rearch results for all and to take full advantage of electronic formats. This is a worthy goal especially if it eliminates needless experimental repetition that would not advance new theory or new treatment. The journals are full of needless replication. Peer reviewers, authors, and editors would all share in the sheer volume of information and the easy access to it A highly centralized type of center involving all the disciplines and their journals along with consideration of non peer-reviewed research material would advance medicine in the millenium. Control of this centralized center is the real problem, but the need for such a center is very apparent. J. Buchanan

Is E-biomed a sound idea? 9 July 1999
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Tapan Das
Albert Einstein College of Medicine

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Re: Is E-biomed a sound idea?

E-biomed seems to vitiate the present system of quality research publication. As pointed out in the editorial by Floyd E. Bloom, there are many questions that need to be answered first. Some of the answers are predictable. For example, the cost of publication would be a major issue if this cost must be born by the authors, particularly when the authors are junior scientists with little or no funding. It will surely affect many authors from non-US countries who, even in the present system, are forced to publish their work only in those journals that do not have mandatory page charges. The second issue is of course, publication of non-peer-reviewed work. If an author refers to a non-peer-reviewed results in a paper that is sent for publication to a peer-reviewed journal, the reviewers will have to essentially judge more than one paper. In fact, authors may not choose to refer to any non-peer-reviewed work for the fear of 'contaminating' their 'good' paper. Then what is the major purpose of publication of a non-peer-reviewed work? A plan to control biomedical research publication by goverment-affiliated agencies can never be healthy for the progress of science.


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