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Science 5 September 2008:
Vol. 321. no. 5894, pp. 1304 - 1305
DOI: 10.1126/science.1163785
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Perspectives

BIOCHEMISTRY:
An Enzyme Assembly Line

Janet L. Smith1,2 and David H. Sherman1,3

Fatty acid synthases and related megaenzymes are highly adaptable to new functions as a result of their modular architecture.

1Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA. E-mail: janetsmith{at}umich.edu

2Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

3Departments of Medicinal Chemistry, Chemistry, and Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA. E-mail: davidhs{at}umich.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Fatty Acid Synthase: Association with Insulin Resistance, Type 2 Diabetes, and Cancer.
J. A. Menendez, A. Vazquez-Martin, F. J. Ortega, and J. M. Fernandez-Real (2009)
Clin. Chem. 55, 425-438
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Science. ISSN 0036-8075 (print), 1095-9203 (online)