IMMUNOLOGY: The Toll of Cathepsin K Deficiency

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Science 1 February 2008:
Vol. 319. no. 5863, pp. 576 - 577
DOI: 10.1126/science.1154207

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Arthur M. Krieg and Grayson B. Lipford

An enzyme that is important to bone metabolism also acts in immune cell responses to pathogen DNA.

The authors are with the Coley Pharmaceutical Group, 93 Worcester Street, Wellesley, MA 02481, USA. E-mail: akrieg{at}coleypharma.com

REPORTS Cathepsin K-Dependent Toll-Like Receptor 9 Signaling Revealed in Experimental Arthritis: Masataka Asagiri, Toshitake Hirai, Toshihiro Kunigami, Shunya Kamano, Hans-Jürgen Gober, Kazuo Okamoto, Keizo Nishikawa, Eicke Latz, Douglas T. Golenbock, Kazuhiro Aoki, Keiichi Ohya, Yuuki Imai, Yasuyuki Morishita, Kohei Miyazono, Shigeaki Kato, Paul Saftig, and Hiroshi Takayanagi (1 February 2008)
Science 319 (5863), 624. [DOI: 10.1126/science.1150110]
| Abstract » | Full Text » | PDF » | Supporting Online Material »

EDITORS' CHOICE
Immunology
T Cell Role for Cathepsin K: Stephen J. Simpson (5 February 2008)
Sci. Signal. 1 (5), ec49. [DOI: 10.1126/stke.15ec49]
| Abstract »

Science. ISSN 0036-8075 (print), 1095-9203 (online)

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