CELL SIGNALING: A Touching Response to Damage

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Science 25 May 2007:
Vol. 316. no. 5828, pp. 1138 - 1139
DOI: 10.1126/science.1143700

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John H. J. Petrini

An extensive network of proteins, and their combinatorial diversity, account for biological functions that are regulated in response to damaged DNA.

Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. E-mail: petrinij{at}mskcc.org

RESEARCH ARTICLES ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage: Shuhei Matsuoka, Bryan A. Ballif, Agata Smogorzewska, E. Robert McDonald, III, Kristen E. Hurov, Ji Luo, Corey E. Bakalarski, Zhenming Zhao, Nicole Solimini, Yaniv Lerenthal, Yosef Shiloh, Steven P. Gygi, and Stephen J. Elledge (25 May 2007)
Science 316 (5828), 1160. [DOI: 10.1126/science.1140321]
| Abstract » | Full Text » | PDF » | Supporting Online Material »

REPORTS Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response: Bin Wang, Shuhei Matsuoka, Bryan A. Ballif, Dong Zhang, Agata Smogorzewska, Steven P. Gygi, and Stephen J. Elledge (25 May 2007)
Science 316 (5828), 1194. [DOI: 10.1126/science.1139476]
| Abstract » | Full Text » | PDF » | Supporting Online Material »

REPORTS RAP80 Targets BRCA1 to Specific Ubiquitin Structures at DNA Damage Sites: Bijan Sobhian, Genze Shao, Dana R. Lilli, Aedín C. Culhane, Lisa A. Moreau, Bing Xia, David M. Livingston, and Roger A. Greenberg (25 May 2007)
Science 316 (5828), 1198. [DOI: 10.1126/science.1139516]
| Abstract » | Full Text » | PDF » | Supporting Online Material »

REPORTS Ubiquitin-Binding Protein RAP80 Mediates BRCA1-Dependent DNA Damage Response: Hongtae Kim, Junjie Chen, and Xiaochun Yu (25 May 2007)
Science 316 (5828), 1202. [DOI: 10.1126/science.1139621]
| Abstract » | Full Text » | PDF » | Supporting Online Material »

EDITORS' CHOICE
Cell Biology
DNA Damage-Response Teams: L. Bryan Ray (29 May 2007)
Sci. STKE 2007 (388), tw189. [DOI: 10.1126/stke.3882007tw189]
| Abstract »

The RAD5-dependent Postreplication Repair Pathway is Important to Suppress Gross Chromosomal Rearrangements.: K. Myung and S. Smith (2008)
J Natl Cancer Inst Monographs 2008, 12-15
| Abstract » | Full Text » | PDF »

Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1.: S. Sivasubramaniam, X. Sun, Y.-R. Pan, S. Wang, and E. Y.-H.P. Lee (2008)
Genes & Dev. 22, 587-600
| Abstract » | Full Text » | PDF »

Science. ISSN 0036-8075 (print), 1095-9203 (online)

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