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GENETICS: Erasing MicroRNAs Reveals Their Powerful Punch
Jennifer Couzin
In a flurry of papers, three of which appear on pages 575, 604, and 608 of this issue of Science, four independent groups have for the first time deleted mouse genes for microRNAs, RNA molecules that can modulate gene behavior, with profound effects. (Read more.)
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In Science Magazine
RESEARCH ARTICLES
Eva van Rooij, Lillian B. Sutherland, Xiaoxia Qi, James A. Richardson, Joseph Hill, and Eric N. Olson (27 April 2007) Science316 (5824), 575.
[DOI: 10.1126/science.1139089] |Abstract »|Full Text »|PDF »|Supporting Online Material »
REPORTS
To-Ha Thai, Dinis Pedro Calado, Stefano Casola, K. Mark Ansel, Changchun Xiao, Yingzi Xue, Andrew Murphy, David Frendewey, David Valenzuela, Jeffery L. Kutok, Marc Schmidt-Supprian, Nikolaus Rajewsky, George Yancopoulos, Anjana Rao, and Klaus Rajewsky (27 April 2007) Science316 (5824), 604.
[DOI: 10.1126/science.1141229] |Abstract »|Full Text »|PDF »|Supporting Online Material »
REPORTS
Antony Rodriguez, Elena Vigorito, Simon Clare, Madhuri V. Warren, Philippe Couttet, Dalya R. Soond, Stijn van Dongen, Russell J. Grocock, Partha P. Das, Eric A. Miska, David Vetrie, Klaus Okkenhaug, Anton J. Enright, Gordon Dougan, Martin Turner, and Allan Bradley (27 April 2007) Science316 (5824), 608.
[DOI: 10.1126/science.1139253] |Abstract »|Full Text »|PDF »|Supporting Online Material »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
miRo: a miRNA knowledge base.
A. Lagana, S. Forte, A. Giudice, M. R. Arena, P. L. Puglisi, R. Giugno, A. Pulvirenti, D. Shasha, and A. Ferro (2009)
Database
2009, bap008
|Abstract »|Full Text »|PDF »
Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells.
N. S. Wickramasinghe, T. T. Manavalan, S. M. Dougherty, K. A. Riggs, Y. Li, and C. M. Klinge (2009)
Nucleic Acids Res.
37, 2584-2595
|Abstract »|Full Text »|PDF »
