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Science 6 October 2006:
Vol. 314. no. 5796, pp. 68 - 69
DOI: 10.1126/science.1133893

Perspectives

CANCER:
Enhanced: Cancer Immunotherapy Is More Than a Numbers Game

Rienk Offringa

White blood cells that are genetically engineered to destroy human melanoma prove effective for a few patients in a clinical trial. A variety of strategies might increase the success rate.


The author is head of the Tumor Immunology Group, Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands. E-mail: r.offringa{at}lumc.nl

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Cancer Res. 68, 2972-2983
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Lentiviral Vectors Encoding Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Receptor Genes Efficiently Convert Peripheral Blood CD8 T Lymphocytes into Cytotoxic T Lymphocytes with Potent In Vitro and In Vivo HIV-1-Specific Inhibitory Activity.
A. Joseph, J. H. Zheng, A. Follenzi, T. DiLorenzo, K. Sango, J. Hyman, K. Chen, A. Piechocka-Trocha, C. Brander, E. Hooijberg, et al. (2008)
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