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Science 6 October 2006: Vol. 314. no. 5796, pp. 68 - 69 DOI: 10.1126/science.1133893
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Perspectives
CANCER: Enhanced: Cancer Immunotherapy Is More Than a Numbers Game
Rienk Offringa
White blood cells that are genetically engineered to destroy human melanoma prove effective for a few patients in a clinical trial. A variety of strategies might increase the success rate.
The author is head of the Tumor Immunology Group, Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands. E-mail: r.offringa{at}lumc.nl
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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- M. Epardaud, K. G. Elpek, M. P. Rubinstein, A.-r. Yonekura, A. Bellemare-Pelletier, R. Bronson, J. A. Hamerman, A. W. Goldrath, and S. J. Turley (2008)
Cancer Res.
68, 2972-2983
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- Lentiviral Vectors Encoding Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Receptor Genes Efficiently Convert Peripheral Blood CD8 T Lymphocytes into Cytotoxic T Lymphocytes with Potent In Vitro and In Vivo HIV-1-Specific Inhibitory Activity.
- A. Joseph, J. H. Zheng, A. Follenzi, T. DiLorenzo, K. Sango, J. Hyman, K. Chen, A. Piechocka-Trocha, C. Brander, E. Hooijberg, et al. (2008)
J. Virol.
82, 3078-3089
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- Functional T Cell Responses to Tumor Antigens in Breast Cancer Patients Have a Distinct Phenotype and Cytokine Signature.
- M. Inokuma, C. dela Rosa, C. Schmitt, P. Haaland, J. Siebert, D. Petry, M. Tang, M. A. Suni, S. A. Ghanekar, D. Gladding, et al. (2007)
J. Immunol.
179, 2627-2633
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