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H-Ras, N-Ras, and K-Ras are homologous signaling molecules that are able to regulate distinct signaling pathways because they inhabit different compartments within the cell. In their Perspective, Meder and Simons discuss new work (Rocks et al.) showing that N-Ras and H-Ras continuously cycle between the plasma membrane and Golgi membranes and that this trafficking depends on whether the Ras isoforms carry a palmitoyl group.
The authors are at the Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany. E-mail: meder{at}mpi-cbg.de, simons{at}mpi-cbg.de
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In Science Magazine
RESEARCH ARTICLES
Oliver Rocks, Anna Peyker, Martin Kahms, Peter J. Verveer, Carolin Koerner, Maria Lumbierres, Jürgen Kuhlmann, Herbert Waldmann, Alfred Wittinghofer, and Philippe I. H. Bastiaens (18 March 2005) Science307 (5716), 1746.
[DOI: 10.1126/science.1105654] |Abstract »|Full Text »|PDF »|Supporting Online Material »
