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GENETICS: Harvesting Medical Information from the Human Family Tree
David Altshuler and Andrew G. Clark
Working with 71 individuals from three diverse human populations, Hinds et al. have characterized more than 1.5 million individual differences in human DNA sequences. In a Perspective, Altshuler and Clark discuss the significance of these findings, their correlation with data from the International Haplotype Map Project, and what both data sets mean for understanding complex human diseases caused by multiple factors.
D. Altshuler is at the Broad Institute of Harvard and Massachusetts Institute of Technology, and at the Massachusetts General Hospital, Boston, MA 02114, USA. E-mail: altshuler{at}molbio.mgh.harvard.edu A. G. Clark is in the Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA. E-mail: ac347{at}cornell.edu
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POLICY FORUM
Troy Duster (18 February 2005) Science307 (5712), 1050.
[DOI: 10.1126/science.1110303] |Summary »|Full Text »|PDF »
RESEARCH ARTICLES
David A. Hinds, Laura L. Stuve, Geoffrey B. Nilsen, Eran Halperin, Eleazar Eskin, Dennis G. Ballinger, Kelly A. Frazer, and David R. Cox (18 February 2005) Science307 (5712), 1072.
[DOI: 10.1126/science.1105436] |Abstract »|Full Text »|PDF »|Supporting Online Material »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Nonlinear Tests for Genomewide Association Studies.
