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Applied Biosytems - Introducing Silencer Select siRNAs

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Science 25 June 2004:
Vol. 304. no. 5679, pp. 1916 - 1917
DOI: 10.1126/science.1100482
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Perspectives

BIOCHEMISTRY:
De Novo Design of an Enzyme

Reinhard Sterner and Franz X. Schmid

Enzymes catalyze biological reactions with amazing efficiency, and years of biochemical research have been directed at understanding how they work. In their Perspective, Sterner and Schmid describe recent work (Dwyer et al.) that brings us closer to the ultimate goal of designing enzymes with tailored activities by using computer design to build catalytic activity onto an inert protein scaffold.

R. Sterner is at the Universität Regensburg, Institut für Biophysik und Physikalische Biochemie, D-93040 Regensburg, Germany. E-mail: reinhard.sterner{at}biologie.uni-regensburg.de. F. X. Schmid is at the Universität Bayreuth, Laboratorium für Biochemie, D-95440 Bayreuth, Germany.

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