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Science 28 May 2004:
Vol. 304. no. 5675, pp. 1253 - 1255
DOI: 10.1126/science.1099344
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Perspectives

NEUROSCIENCE:
Cellular Interactions in the Stem Cell Niche

Andrew E. Wurmser, Theo D. Palmer, Fred H. Gage

Stem cells are capable of both self-renewal and differentiation into many different cell types. These hallmark characteristics are regulated by other cells within the stem cell niche. In their Perspective, Wurmser et al. discuss the finding that endothelial cells in the neural stem cell niche secrete factors that influence neural stem cells to proliferate and become neurons (Shen et al.).

A. E. Wurmser and F. H. Gage are in the Laboratory of Genetics, Salk Institute, La Jolla, CA 92037, USA. T. D. Palmer is in the Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA. E-mail: gage{at}salk.edu

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