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Science 23 January 2004:
Vol. 303. no. 5657, pp. 479 - 480
DOI: 10.1126/science.1094231
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Perspectives

CELL BIOLOGY:
BAR Domains Go on a Bender

Marcus C. S. Lee and Randy Schekman

How do cells make vesicles, a process that requires the bending of membranes? In their Perspective, Lee and Schekman discuss new findings (Peter et al.) that identify a domain called the BAR domain in proteins, such as amphiphysin and endophilin, that induces the curvature of membranes at different points during vesicle formation.

The authors are in the Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA. E-mail: schekman{at}uclink4.berkeley.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Autoinhibition of Arf GTPase-activating Protein Activity by the BAR Domain in ASAP1.
X. Jian, P. Brown, P. Schuck, J. M. Gruschus, A. Balbo, J. E. Hinshaw, and P. A. Randazzo (2009)
J. Biol. Chem. 284, 1652-1663
   Abstract »    Full Text »    PDF »
APPL1: role in adiponectin signaling and beyond.
S. S. Deepa and L. Q. Dong (2009)
Am J Physiol Endocrinol Metab 296, E22-E36
   Abstract »    Full Text »    PDF »
The mouth of a dense-core vesicle opens and closes in a concerted action regulated by calcium and amphiphysin.
A. Llobet, M. Wu, and L. Lagnado (2008)
J. Cell Biol. 182, 1017-1028
   Abstract »    Full Text »    PDF »
Modes of Vesicle Retrieval at Ribbon Synapses, Calyx-Type Synapses, and Small Central Synapses.
L.-G. Wu, T. A. Ryan, and L. Lagnado (2007)
J. Neurosci. 27, 11793-11802
   Full Text »    PDF »
The BAR Domain Proteins: Molding Membranes in Fission, Fusion, and Phagy.
G. Ren, P. Vajjhala, J. S. Lee, B. Winsor, and A. L. Munn (2006)
Microbiol. Mol. Biol. Rev. 70, 37-120
   Abstract »    Full Text »    PDF »
Characterization of the Yeast Amphiphysins Rvs161p and Rvs167p Reveals Roles for the Rvs Heterodimer In Vivo.
H. Friesen, C. Humphries, Y. Ho, O. Schub, K. Colwill, and B. Andrews (2006)
Mol. Biol. Cell 17, 1306-1321
   Abstract »    Full Text »    PDF »
Interaction of the Saccharomyces cerevisiae Cortical Actin Patch Protein Rvs167p With Proteins Involved in ER to Golgi Vesicle Trafficking.
H. Friesen, K. Colwill, K. Robertson, O. Schub, and B. Andrews (2005)
Genetics 170, 555-568
   Abstract »    Full Text »    PDF »
VAN3 ARF-GAP-mediated vesicle transport is involved in leaf vascular network formation.
K. Koizumi, S. Naramoto, S. Sawa, N. Yahara, T. Ueda, A. Nakano, M. Sugiyama, and H. Fukuda (2005)
Development 132, 1699-1711
   Abstract »    Full Text »    PDF »
Cellugyrin Induces Biogenesis of Synaptic-like Microvesicles in PC12 Cells.
G. M. Belfort, K. Bakirtzi, and K. V. Kandror (2005)
J. Biol. Chem. 280, 7262-7272
   Abstract »    Full Text »    PDF »


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