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Science 26 September 2003:
Vol. 301. no. 5641, pp. 1859 - 1860
DOI: 10.1126/science.1090465
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Perspectives

CELL BIOLOGY:
An Age of Instability

David A. Sinclair

It is well established that as we age our cancer risk increases dramatically. As Sinclair explains in his Perspective, the link between cancer and aging is now solidified by new work in budding yeast (McMurray and Gottschling). As yeast cells age there is a marked increase in their genetic instability (a hallmark of cancer), which is independent of the mechanism that determines their life-span.

The author is in the Department of Pathology, Harvard Medical School, Boston, MA 02115, USA. E-mail: david_sinclair{at}hms.harvard.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Metal-catalyzed Oxidation of the Werner Syndrome Protein Causes Loss of Catalytic Activities and Impaired Protein-Protein Interactions.
J. A. Harrigan, J. Piotrowski, L. Di Noto, R. L. Levine, and V. A. Bohr (2007)
J. Biol. Chem. 282, 36403-36411
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