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Science 27 June 2003:
Vol. 300. no. 5628, pp. 2045 - 2046
DOI: 10.1126/science.1087148

Perspectives

BIOPHYSICS:
Myosin Motors Walk the Walk

Justin E. Molloy and Claudia Veigel

Myosin molecular motors move along actin filaments to drive, for example, muscle contraction or the intracellular trafficking of vesicles. However, it has not been clear whether myosin V moves along actin filaments in a hand-over-hand or inchworm fashion. In their Perspective, Molloy and Veigel explain new work (Yildiz et al.) that provides evidence in support of the hand-over-hand model for how myosin V walks along actin.


The authors are in the Division of Physical Biochemistry, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK. E-mail: jmolloy{at}nimr.mrc.ac.uk

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Elastic Lever-Arm Model for Myosin V.
A. Vilfan (2005)
Biophys. J. 88, 3792-3805
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Science. ISSN 0036-8075 (print), 1095-9203 (online)