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Science 7 February 2003:
Vol. 299. no. 5608, pp. 846 - 849
DOI: 10.1126/science.299.5608.846
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Cellular Warriors at the Battle of the Bulge

Jean Marx

The tools of molecular genetics have yielded a rush of new information about molecular signals that regulate body weight. Some guide short-term decisions, such as whether to eat now or push away from the table. Other molecules take a longer view, monitoring fat balance. One message coming out of this work is depressing for people who want to lose weight: The body's weight-control systems have apparently been designed to protect more against weight loss than weight gain.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)