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Science 7 February 2003:
Vol. 299. no. 5608, pp. 846 - 849
DOI: 10.1126/science.299.5608.846
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News

Cellular Warriors at the Battle of the Bulge

Jean Marx

The tools of molecular genetics have yielded a rush of new information about molecular signals that regulate body weight. Some guide short-term decisions, such as whether to eat now or push away from the table. Other molecules take a longer view, monitoring fat balance. One message coming out of this work is depressing for people who want to lose weight: The body's weight-control systems have apparently been designed to protect more against weight loss than weight gain.

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Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys.
H. D. Sun, M. Malabunga, J. R. Tonra, R. DiRenzo, F. E. Carrick, H. Zheng, H.-R. Berthoud, O. P. McGuinness, J. Shen, P. Bohlen, et al. (2007)
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Glucose sensing by hypothalamic neurones and pancreatic islet cells: AMPle evidence for common mechanisms?.
P. D. Mountjoy and G. A. Rutter (2007)
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Parathyroid Hormone-Related Protein Induces Cachectic Syndromes without Directly Modulating the Expression of Hypothalamic Feeding-Regulating Peptides.
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Factor analysis of fatty acids in serum lipids as a measure of dietary fat quality in relation to the metabolic syndrome in men..
E. Warensjo, J. Sundstrom, L. Lind, and B. Vessby (2006)
Am. J. Clinical Nutrition 84, 442-448
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Neonatal Leptin Treatment Reverses Developmental Programming.
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Endocrinology 146, 4211-4216
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Effects of high-fat diets with different carbohydrate-to-protein ratios on energy homeostasis in rats with impaired brain melanocortin receptor activity.
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Am J Physiol Regulatory Integrative Comp Physiol 289, R156-R163
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Current Models and Future Directions for Understanding the Neural Circuitries of Maternal Behaviors in Rodents.
S. C. Gammie (2005)
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Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin.
A Asakawa, A Inui, M Fujimiya, R Sakamaki, N Shinfuku, Y Ueta, M M Meguid, and M Kasuga (2005)
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Early changes in insulin secretion and action induced by high-fat diet are related to a decreased sympathetic tone.
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Leptin and the Control of Metabolism: Role for Stearoyl-CoA Desaturase-1 (SCD-1).
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Historic and Early Life Origins of Hypertension in Africans.
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J. Nutr. 134, 211-216
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An Update on the Obesity Problem.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)