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Science 20 December 2002:
Vol. 298. no. 5602, pp. 2296 - 2297
DOI: 10.1126/science.298.5602.2296
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News

BREAKTHROUGH OF THE YEAR:
Small RNAs Make Big Splash

Jennifer Couzin

Just when scientists thought they had deciphered the roles played by the cell's leading actors, a familiar performer has turned up in a stunning variety of guises. RNA, long upstaged by its more glamorous sibling, DNA, is turning out to have star qualities of its own. Science hails these electrifying discoveries, which are prompting biologists to overhaul their vision of the cell and its evolution, as 2002's Breakthrough of the Year. The online version of the Breakthrough of the Year section contains references and links not found in the print edition (see www.sciencemag.org/content/vol298/issue5602/#special).

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Solution structure of a let-7 miRNA:lin-41 mRNA complex from C. elegans.
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Nucleic Acids Res. 36, 2330-2337
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MicroRNA-target pairs in the rat kidney identified by microRNA microarray, proteomic, and bioinformatic analysis.
Z. Tian, A. S. Greene, J. L. Pietrusz, I. R. Matus, and M. Liang (2008)
Genome Res. 18, 404-411
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Mortal and Immortal DNA: Craig Venter and Keats' "Lamia".
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Review of the Application of RNA Interference Technology in the Pharmaceutical Industry.
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RNA interference as potential therapy for neurodegenerative disease: Applications to inclusion-body myositis?.
H. Paulson (2006)
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MARNA: multiple alignment and consensus structure prediction of RNAs based on sequence structure comparisons.
S. Siebert and R. Backofen (2005)
Bioinformatics 21, 3352-3359
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Apical ammonia transport by the mouse inner medullary collecting duct cell (mIMCD-3).
M. E. Handlogten, S.-P. Hong, C. M. Westhoff, and I. D. Weiner (2005)
Am J Physiol Renal Physiol 289, F347-F358
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A statistical analysis of RNA folding algorithms through thermodynamic parameter perturbation.
D. M. Layton and R. Bundschuh (2005)
Nucleic Acids Res. 33, 519-524
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Monte Carlo Simulation for Single RNA Unfolding by Force.
F. Liu and Z.-c. Ou-Yang (2005)
Biophys. J. 88, 76-84
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Efficient computation of optimal oligo-RNA binding.
N. O. Hodas and D. P. Aalberts (2004)
Nucleic Acids Res. 32, 6636-6642
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Fair Attribution of Functional Contribution in Artificial and Biological Networks.
A. Keinan, B. Sandbank, C. C. Hilgetag, I. Meilijson, and E. Ruppin (2004)
Neural Comput. 16, 1887-1915
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RNA Silencing in Surgical Disease--Invited Critique.
S. F. Lowry (2003)
Arch Surg 138, 1148
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Minerva.
(2003)
BMJ 326, 60
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Science. ISSN 0036-8075 (print), 1095-9203 (online)