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Science 13 September 2002:
Vol. 297. no. 5588, pp. 1822 - 1823
DOI: 10.1126/science.1077171
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Perspectives

CANCER:
BRCA2 Enters the Fray

John H. Wilson and Stephen J. Elledge

Inherited mutations in the BRCA2 gene confer an increased risk of breast and ovarian cancer on affected individuals. BRCA2 is thought to be important in the repair of DNA double-strand breaks induced by, for example, ionizing radia-tion. In a Perspective, Wilson and Elledge dis-cuss a new structural study (Yang et al.) that provides compelling evidence that BRCA2 is a crucial player in homologous DNA repair.

J. H. Wilson and S. J. Elledge are in the Verna and Marrs McLean Department of Biochemistry and Molecular Biology, and the Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. S. J. Elledge is also with the Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA. E-mail: selledge{at}bcm.tmc.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Molecular pathogenesis of Fanconi anemia: recent progress.
T. Taniguchi and A. D. D'Andrea (2006)
Blood 107, 4223-4233
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Science. ISSN 0036-8075 (print), 1095-9203 (online)