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Science 12 July 2002:
Vol. 297. no. 5579, pp. 174 - 175
DOI: 10.1126/science.297.5579.174b
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News of the Week

VIROLOGY:
Active Poliovirus Baked From Scratch

Jennifer Couzin

With mail-order DNA and more than 2 years of painstaking work, researchers for the first time have assembled a virus from its chemical code. The lab-built poliovirus, described online this week by Science, killed mice and was almost indistinguishable from the original. Biologists disagree on how difficult it would be to construct far bulkier viruses such as smallpox to create bioweapons.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)