Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Whatman Inc.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Originally published in Science Express on 23 May 2002
Science 5 July 2002:
Vol. 297. no. 5578, pp. 61 - 62
DOI: 10.1126/science.1073910
Prev | Table of Contents | Next

Perspectives

BIOCHEMISTRY:
DNA Building Block Reinvented

Alexey G. Murzin

It might be assumed that mechanisms for the biosynthesis of essential DNA precursors would be conserved in all organisms. However, Murzin discusses new work (Myllykallio et al.) showing that a large family of enzymes, named ThyX, synthesize thymidylate by an alternate mechanism. The structure of ThyX has been determined independently and together these findings pave the way for rational drug design.

The author is in the MRC Centre for Protein Engineering, Hills Road, Cambridge CB2 2QH, UK. E-mail: agm{at}mrc-lmb.cam.ac.uk

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Catalytic Mechanism of Chlamydia trachomatis Flavin-dependent Thymidylate Synthase.
J. Griffin, C. Roshick, E. Iliffe-Lee, and G. McClarty (2005)
J. Biol. Chem. 280, 5456-5467
   Abstract »    Full Text »    PDF »
Functional evidence for active site location of tetrameric thymidylate synthase X at the interphase of three monomers.
D. Leduc, S. Graziani, G. Lipowski, C. Marchand, P. Le Marechal, U. Liebl, and H. Myllykallio (2004)
PNAS 101, 7252-7257
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products