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A growing body of evidence suggests that a molecular marker for inflammation known as C-reactive protein (CRP) may be as crucial as cholesterol deposition and clogged arteries in assessing risk of heart attack. That discovery, the result of considerable work over the past decade, has spawned more questions, starting with the most fundamental one: Does the presence of inflammation trigger rising CRP levels that lead to heart disease, or is inflammation a byproduct of the disease? The answer could greatly affect the standard of care for the disease, from early diagnosis through treatment.
Fc{gamma}RIIa expression with Fc{gamma}RI results in C-reactive protein- and IgG-mediated phagocytosis.
K. B. Bodman-Smith, R. E. Gregory, P. T. Harrison, and J. G. Raynes (2004)
J. Leukoc. Biol.
75, 1029-1035
|Abstract »|Full Text »|PDF »
IL-1 Induces Vesicular Secretion of IL-6 without Degranulation from Human Mast Cells.
K. Kandere-Grzybowska, R. Letourneau, D. Kempuraj, J. Donelan, S. Poplawski, W. Boucher, A. Athanassiou, and T. C. Theoharides (2003)
J. Immunol.
171, 4830-4836
|Abstract »|Full Text »|PDF »
Aging, Progenitor Cell Exhaustion, and Atherosclerosis.
F. M. Rauscher, P. J. Goldschmidt-Clermont, B. H. Davis, T. Wang, D. Gregg, P. Ramaswami, A. M. Pippen, B. H. Annex, C. Dong, and D. A. Taylor (2003)
Circulation
108, 457-463
|Abstract »|Full Text »|PDF »
New Markers for Cardiovascular Disease Risk in Women: Impact of Endogenous Estrogen Status and Exogenous Postmenopausal Hormone Therapy.
S. Davison and S. R. Davis (2003)
J. Clin. Endocrinol. Metab.
88, 2470-2478
|Abstract »|Full Text »|PDF »
Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids.
J. Y. Lee, A. Plakidas, W. H. Lee, A. Heikkinen, P. Chanmugam, G. Bray, and D. H. Hwang (2003)
J. Lipid Res.
44, 479-486
|Abstract »|Full Text »|PDF »
Is Metabolic Syndrome X an Inflammatory Condition?.
U. N. Das (2002)
Experimental Biology and Medicine
227, 989-997
|Abstract »|Full Text »
Oxidized phosphatidylcholines: Pattern recognition ligands for multiple pathways of the innate immune response.
S. L. Hazen and G. M. Chisolm (2002)
PNAS
99, 12515-12517
|Full Text »|PDF »
